ID H2SZ28_TAKRU Unreviewed; 763 AA.
AC H2SZ28;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Olfactory receptor C family, u1 {ECO:0000313|Ensembl:ENSTRUP00000017666.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000017666.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000017666.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000017666.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2SZ28; -.
DR Ensembl; ENSTRUT00000017740.3; ENSTRUP00000017666.2; ENSTRUG00000007182.3.
DR GeneTree; ENSGT00940000166814; -.
DR InParanoid; H2SZ28; -.
DR OMA; RTMIFCT; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF546; OLFACTORY RECEPTOR C FAMILY, U1 PRECURSOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 499..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 499..761
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 763 AA; 85006 MW; 70EB106E5E30505D CRC64;
MDRSFLSCWG FTLLLWAISS IFFPVFSGLQ HIAKEKNDTH GLEAGDGNDA SPSLPRCVKT
VDTQRPALHS RGDVMIGGIF PLHYSASVSQ QKYINKPELI TCSGFDHRAF RWMMTMVFAV
NEINNNSSLL PGVKLGYRIL DGCDHVPTSL QALLYLNSTV SEESMTWKQV EEMIPACLAD
SPVSYFATCT CLSDKSTYPS FLRTVPSDLF QVRGLVQMVT FMSWLWVGTI GTTDDYSHYG
IQAFSHQLRQ QGGCVEFQLT IPKSPTAAEL KEMADRLQSS TARVVVVFAT EGQLLEFFLE
LIYRNMTGIQ WVASEAWVTA SLLTTPRFHA LLEGTLGFSF PGAEIPGLKE FLLNICPSPK
PGMEFVNMFW EDLFGCKLNS DTKSADESPV CTGSEDLRYT QSSYTDVSQV RISYNVYKAV
YAIAHALHSL LNCESPGSNV GTCKKREPFT SKQVPNYGQI SNQTGSTECQ RCPEYYWPDK
DKVKCLPGIE EFLSFSETMG IILVILTLVG VLLTFSLTII FLHFRSTPIV KANNSEISFL
LLLSLKLCFL CSLLFIGQPS LWKCRLRQAA FGISFVLCLS CLLVKTIVVL FAFRTNLRAG
CCALKLFGPS RQRTLILCTT APQVCLCAGW LLAAPSFPVR NPAYQIVLEC KEPWPPGFYL
VLGYIGLLAF LCLLLAFVGR KLPNTFNEAK LITFSLLIFW AVWISFIPAY VSSPGKFTVA
VEVFAILASS FGLLLCIFLP KCFIILLRPE RNVKKGMTGK CLR
//
