ID H2T0I7_TAKRU Unreviewed; 1229 AA.
AC H2T0I7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 24-JAN-2024, entry version 65.
DE SubName: Full=Membrane associated guanylate kinase, WW and PDZ domain containing 1 {ECO:0000313|Ensembl:ENSTRUP00000018175.3};
GN Name=magi1 {ECO:0000313|Ensembl:ENSTRUP00000018175.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000018175.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000018175.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000018175.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
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DR AlphaFoldDB; H2T0I7; -.
DR Ensembl; ENSTRUT00000018251.3; ENSTRUP00000018175.3; ENSTRUG00000007355.3.
DR GeneTree; ENSGT00940000155820; -.
DR HOGENOM; CLU_004562_1_0_1; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 6.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.42.10; -; 6.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR10316; MEMBRANE ASSOCIATED GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR10316:SF12; MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF16663; MAGI_u1; 1.
DR Pfam; PF16666; MAGI_u5; 1.
DR Pfam; PF00595; PDZ; 6.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 6.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 6.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443}.
FT DOMAIN 17..100
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 108..190
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 312..345
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 448..517
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 632..710
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 824..882
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 962..1058
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1125..1207
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 183..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..772
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 898..912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1093
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 132884 MW; 5011803DBC19D426 CRC64;
MSKPAAKKNH WTSRVNECSV SKDARGDLNV PLRGGAENGE FAYIGHVNED VVVYKSGKLN
EGELLLEVEN LSISGLPLYD IQTLIKNCKG PVRLKTVRQG NKLNKDLKHY LSQRFQKSSP
DHELQQTIRD NLYRHAVPCT TRAPREGEVP GVDYNFLSVE DFFKLENSGT LLEIGTYEGN
YYGTPRPPVQ PPGGKVISSG GDAPLPDGLS GSLPGSQHST PRRSKSYNDM QNAGIGPGEQ
QQEDDEDLPD MNSSFTGDSS ELDEIHHSVR PFAPHRSDPS YPGTTPSPTA TTESTQQTHS
HLSHPPSEDP LGPLPDNWEM AYTEDGEVYF IDHNTKTTSW VDPRCLNKPQ KPLEECEDDG
IHINRKTQYE NPVLEAKRRR QLEQQPQPQK WIEDSALAGA PLASYAATQQ ETYRDPQTGP
TVPSAMGQKR GKPFFTRNRS ELKGTFINTK LKKSRRGFGF TVVGGDEPDE FLQIKSLVLD
GPAALDGKME TGDVIVSVND TCVLGYTHAQ VVKIFQSIPI GSMVNLELCR GYPLPFDPDD
PNTSLVTSVA ILENKDPIIV NGQEAPNSYD SPSNHGSQNN NSSSNGGAPL NGLPRPCSPS
VEVASDTSSQ HGYPSDVVTL ASSIATQPEL ITVHMEKGEK GFGFTIADSP GGGGQRVKQI
VDYPRCRGLK EGDIIVEVNK RNVQSMSHNE VVNLLSKCSK GSEVTMLVQR GVATAKKSPK
LQLSRKDSQN SSQHSVSSHR SIHTDSPAHS SLAAPLSESV APPPPSQPLP SLPTQDSPAD
GTIQRKPDPF KIWAQSRSMY ESRRKYIIFG GEMCLSAPFC VFQIYIGHIV KFGAADEDGR
LRSGDELICV DGTAVVGKSH QLVVQLMQQA AKQGHVNLTV RRKTSYAVKA EGDVPPSPAS
SHHSSTQAPS LTEEIGKRTL QGSQNSLNTV SSGSGSTSGI GSGGGGVGGG ANTVVPAAAP
YDVEIRRGEN EGFGFVIVSS VSRPEAGTTF AGNACVAMPH KIGRIIEGSP ADRCGKLKVG
DRILAVNGCS ITNKSHSDIV NLIKEAGNTV TLRIIPGDES SNASLLTNAE KIATITTTHT
PQQQAAPETR TNTKPKQESY EFKAPQAPPP QPPTQISPQD AEFYSVDLER DNKGFGFSLR
GGREYNMDLY VLRLAEDGAA VRNGKMRVGD EILEINGEST KGMKHARAIE LIKSGGRRVH
LVLKRGDGSV PEYGGSIYEN IPFSPIFTP
//