ID H2T0S3_TAKRU Unreviewed; 644 AA.
AC H2T0S3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Fermitin family member 1 {ECO:0000313|Ensembl:ENSTRUP00000018261.3};
GN Name=FERMT1 {ECO:0000313|Ensembl:ENSTRUP00000018261.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000018261.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000018261.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000018261.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; H2T0S3; -.
DR STRING; 31033.ENSTRUP00000077082; -.
DR Ensembl; ENSTRUT00000018337.3; ENSTRUP00000018261.3; ENSTRUG00000007385.3.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17180; FERM_F0_KIND1; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF12; FERMITIN FAMILY HOMOLOG 1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 343..439
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 644 AA; 74479 MW; 1C56ADB272C35579 CRC64;
CLGYYEEMSW ELSVQIDQKS GDEAMKFKLR VKGDLHIGGL MLKLVEKIKA PQDWSDHALW
WEQRKCWLLK THWTLDKYGI QADADLRYTP QHKPLLVQLP NMKTILLTVS FSSVVFKTVA
DICRILNLRR SEELSLLKPP DDASNKKKKK DKNAREDIWD IDLFSGTSGA AVSQGFSIYF
FDVSAAECLP NLPPAELAKI YQPLSLVDKA NNFSGWLDSS RSLMEQDVQD EDKLLLRFKY
HVFFDLNPKY DAVRITQLYE QARWNILLEE IDCTEEEMLM FASLQYHICK LTLSNEPLDH
SKEPEIDEVE AALSNLEVTL EGGHTDKILE DITDIPELAD TLRLFRPKRL TLRPYKEYWF
VFKDTTISYF KNKEASYGEP IEQFHLRGCE VVPDVNVTDK KFGIKLLLPV ADGMNEIYIR
CNNETQYAKW KAACILASKG KTMAYSSYKS EVRNIQSFLQ MKSLAPPPGQ ATPDLDTMEM
NAECFVSPRY AKKHKTKQLT TRILEAHQNI ANLSLMEAKM RFIQAWQSLP EFGIKYYIVR
FKGSKKDEIL GISYNRMFRI DMSTGLPVTT WRFANIKQWN VNWEIRQVAI EFDQNVSIAF
CCLSCDCKVV HEFIGGYIFL STRSKDQNET LDEELFHKLT GGQD
//
