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Database: UniProt
Entry: H2T1B7_TAKRU
LinkDB: H2T1B7_TAKRU
Original site: H2T1B7_TAKRU 
ID   H2T1B7_TAKRU            Unreviewed;       282 AA.
AC   H2T1B7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 54.
DE   RecName: Full=Tissue factor {ECO:0000256|ARBA:ARBA00018722};
DE   AltName: Full=Coagulation factor III {ECO:0000256|ARBA:ARBA00031171};
GN   Name=LOC101061223 {ECO:0000313|Ensembl:ENSTRUP00000018455.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000018455.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000018455.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000018455.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Initiates blood coagulation by forming a complex with
CC       circulating factor VII or VIIa. The [TF:VIIa] complex activates factors
CC       IX or X by specific limited proteolysis. TF plays a role in normal
CC       hemostasis by initiating the cell-surface assembly and propagation of
CC       the coagulation protease cascade. {ECO:0000256|ARBA:ARBA00002201}.
CC   -!- SUBUNIT: Interacts with HSPE; the interaction, inhibited by heparin,
CC       promotes the generation of activated factor X and activates coagulation
CC       in the presence of activated factor VII.
CC       {ECO:0000256|ARBA:ARBA00011184}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the tissue factor family.
CC       {ECO:0000256|ARBA:ARBA00009197}.
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DR   RefSeq; XP_003975537.1; XM_003975488.2.
DR   AlphaFoldDB; H2T1B7; -.
DR   STRING; 31033.ENSTRUP00000018455; -.
DR   Ensembl; ENSTRUT00000018531.3; ENSTRUP00000018455.2; ENSTRUG00000007454.3.
DR   GeneID; 101061223; -.
DR   KEGG; tru:101061223; -.
DR   eggNOG; ENOG502RA1F; Eukaryota.
DR   GeneTree; ENSGT00390000012668; -.
DR   InParanoid; H2T1B7; -.
DR   OMA; NPYRESN; -.
DR   OrthoDB; 5321079at2759; -.
DR   TreeFam; TF352627; -.
DR   Proteomes; UP000005226; Chromosome 22.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR   InterPro; IPR001187; Tissue_factor.
DR   PANTHER; PTHR20859; INTERFERON/INTERLEUKIN RECEPTOR; 1.
DR   PANTHER; PTHR20859:SF22; TISSUE FACTOR; 1.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   PRINTS; PR00346; TISSUEFACTOR.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
PE   3: Inferred from homology;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..282
FT                   /note="Tissue factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017195995"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          11..103
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|Pfam:PF01108"
FT   DOMAIN          134..233
FT                   /note="Interferon/interleukin receptor"
FT                   /evidence="ECO:0000259|Pfam:PF09294"
SQ   SEQUENCE   282 AA;  31954 MW;  EC86B44141001F74 CRC64;
     MALKWILHLG IYLSTLIIST ADLNLAPKAE NVQWMSLDFK TVLIWSPSPS KYSYTVSYFY
     DERYYEDTPD CIRLSESECD LTHCLQPLDR TYYARIQTEP ETMDNEDNLE ELPHTISPSF
     NPYRESNISA VTFTVKNVNE TTVLVNITDP LTSIYEQGEQ LTIRDILKKD LQYKISYYKT
     GSTGKKDIIS NTSEAVVPDL DPGQSYCFMV AAYIPSRPKA SRHGALSGQS CIRRKTELSP
     EAWIAIVLTA ITIIIIVVIV LYCKCCRGTN QNLQMTQSSA PL
//
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