ID H2T385_TAKRU Unreviewed; 1229 AA.
AC H2T385;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=PTPRF interacting protein alpha 1 {ECO:0000313|Ensembl:ENSTRUP00000019123.3};
GN Name=ppfia1 {ECO:0000313|Ensembl:ENSTRUP00000019123.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019123.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019123.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019123.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR AlphaFoldDB; H2T385; -.
DR Ensembl; ENSTRUT00000019201.3; ENSTRUP00000019123.3; ENSTRUG00000007699.3.
DR GeneTree; ENSGT01050000244900; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF15; LIPRIN-ALPHA-1; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 873..939
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 997..1054
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1078..1147
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..133
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 258..446
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 472..499
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 216..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 138856 MW; 6E258784523E08F8 CRC64;
MMCEVMPTIS EAEGPNGGNG ASRRGSGSPL HSDSEGHFES LMVSMLEERD RLLDTLRETQ
ENLGLTQSKL HEVSHERDSL QRQLNTALPQ EFAALTKEVN ICREQLLEKE EEIAELKAER
NNTRLLLEHL ECLVSRHERS LRMTVVKRQA QSPAGVSSEV EVLKALKSLF EHHKALDEKV
RERLRVALER CSVLEEQLTV SHKELAYHRE QSSQRRGLAD GTSEVNHNSE NTPSTNGKRA
SDGSQNHEEE SEPVFGKVSE LQDVVDRQTA DLGQMKERMA TMVSRISELE EDLDTARKDL
IKSEDMNTRL QRDLRESMAQ KEDMEERITT LEKRYLAAQR EATSVHDLND KLENEVANKE
SLFKQSEDKN RQLQEKLELA EQKLQQTIRK AETLPEVEAE LAQRVAALTK AEERHGNVEE
RLRQLEAQLE EKNQELLRAR QREKMNEEHN KRLSDTVDKL LSESNERLQL HLKERMSALE
EKNNLIRELE HTKKLIEDSH HEKVRDSFSF CTHCLGMVNT PDFRFPVSSS SMMDSNSEHY
GGALVQRRPQ KGRMAALRDE PSKVQTLNEQ EWERMQQANV LANVAQAFES DMDASDLDED
RETIFSSADL LSPAGQADAQ TLALMLQEQL DAINNEIRMI QEEKESTAIR AEEIECRVGS
NDGLGGRFRS MSSIPPSLCM GSSVGGSPPG SGHSTPRRIP RSPNRELDRM GVMTLPSDLR
KHRRKATQED KATIHCETSP PTTPRSMRLN RETCHASSHE DIRDIRGLSG LQDGQGSNPS
SSNSSQDSLN KAAKKKSIKS SIGRLFGKKE KGRPSIPGKD STSQAGTPES ESSPKDGLGM
GTLGGPAEKN RKLQKKHELL EEARRQGLPF AQWDGPTVVS WLELWVGMPA WYVAACRANV
KSGAIMSALS DTEIQREIGI SNPLHRLKLR LAIQEIMSLT SPSAPPTSRT TTGNVWVTHE
EMESLAATPT TVCVNLSPLW QQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMESLVDARM
LDHLTKKDLR GQLKMVDSFH RNSFQCGVMC LRRLNYDRKE LEKKRETSQM DLQDVLVWSN
ERVISWVQAI GLKEYSSNLY ESGVHGALLA LDEMFDHNAL ALLLQIPTQN TQARATLERE
YNSLLAFGTD RRVEEDDDKN FRRAPSWRKK FRPKDMRGMS LGVSDTLPAN FRVTGSNAAS
PSMQPKRSAM DGSQSIQRLD TATVRTYSC
//
