ID H2T3C1_TAKRU Unreviewed; 748 AA.
AC H2T3C1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=TLE family member 2, transcriptional corepressor a {ECO:0000313|Ensembl:ENSTRUP00000019159.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019159.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019159.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019159.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR AlphaFoldDB; H2T3C1; -.
DR Ensembl; ENSTRUT00000019237.3; ENSTRUP00000019159.3; ENSTRUG00000007715.3.
DR GeneTree; ENSGT01030000234519; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 39..122
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 548..589
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 590..631
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 146..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 79289 MW; E65876A03BEDF297 CRC64;
MFPQNRPPAP LQPPPGSSAS VVAAAAAAAA AASGTPQSLK LTYPETLDRI KEEFQFLQTQ
YHSLKLECEK LATEKTEIQR HYVMYYEMSY GLNIEMHKQT EIAKRLNVIC AQLIPFLSQE
HRSLRSLFCL PSPLCSSLQQ QLQAQHLSQH AQGLPMGPHP SGLPHPGLAL GGGSGLLALS
GALGAQLAAK DERAHLEAVA AAAAAAADHH RGTAASPHCL KAERVNVAFT SEPEMNDPSS
PRSVQSYSSR ENGLDKMPPS RKDGPPQASP TSLASSSSAA SPSRGKEPPQ VETDASTPGM
KPGTPMSQES NTPGPSGPPQ FRPVPGKPGV ELALGLRNPL AVQGAYPPGA FGLPPHGVNG
DLPGAAGYGA GLHLVSPQMN GAAAAAAAAA AAGYGRSPVS PHPHMRVPGL PASLQSAASG
KPAYSFHVSA DGQMQPVPFP PDALLGPGIP RHARQIHSLN HGEVVCAVTI SASTRHVYTG
GKGCVKVWDI SQPGTKSPMA QLDCLNRDNY IRSCKLLSDG RTLIVGGEAS TLSIWDLATP
TPRIKAELTS SAPACYALAI SPDNKVCFSC CSDGNIVVWD LHNQTLVRQF QGHTDGASCI
DISNDGTKLW TGGLDNTVRC WDLREGRQLQ QHDFTSQIFS LGYCPTGEWL AVGMESSNVE
VLHVSKPDKY QLHLHESCVL SLKFAYCGKW FVSTGKDNLL NAWRTPYGSS IFQSKESSSV
LSCDISPDDQ FIVTGSGDKK ATVYEVIY
//
