ID H2T4B1_TAKRU Unreviewed; 1210 AA.
AC H2T4B1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Zinc finger CCCH-type containing 4 {ECO:0000313|Ensembl:ENSTRUP00000019499.3};
GN Name=ZC3H4 {ECO:0000313|Ensembl:ENSTRUP00000019499.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019499.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019499.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019499.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2T4B1; -.
DR STRING; 31033.ENSTRUP00000019499; -.
DR Ensembl; ENSTRUT00000019578.3; ENSTRUP00000019499.3; ENSTRUG00000007843.3.
DR GeneTree; ENSGT00940000160011; -.
DR InParanoid; H2T4B1; -.
DR OMA; MGKKIPS; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR045124; Su(sable)-like.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR13119; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI; 1.
DR PANTHER; PTHR13119:SF23; ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF90229; CCCH zinc finger; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 242..269
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 271..308
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 242..269
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 271..308
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 878..911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..126
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..161
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..203
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..365
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..443
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..546
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..780
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..958
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1099
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 126993 MW; C33AE30D243EFBB9 CRC64;
MAVESMTVHP NSPTTNHEHN SLLTDERSSN STSHGCYSGA KKGSYMKMDK KTYGGYDDYE
EDNYEAEEDE EMVDEDYDDF AKELNQYRKA KEGGHPRGGR GRGRMKGQRG RGGMRGGRRG
KGRGRGCRIG GGKMGDDDGD GYVDEMEYGD DDYDNMGDDD YDDFSKELNQ YKKSKDRGRG
GKGGRGRGRG KGGRGMMRGG RGRNRGRGRM DMGMDDDHND GGGGGDGPGH GRRNQNDKHQ
DKKGKAICKY YIEGRCTWGD HCNFSHDVDL PKKKELCKFY ITGFCARLFH TTGNCVNNDE
CMFSHEALND DTKELLNKML AEDAEAGAED EKEVEELKKQ GINPLPKPPP GVGLLPTPPR
PIPVEATTAP GDFGGPGAND FGSGPLGPGP VPGPPPCGGF PGPIPGPGPC PGPGPGPGPE
GNPFQGPPPN TGGPPPHMGP PPPMGGGGGG GGKKIPSLFE IKVQPTGQLA QKLSWIFSNG
QTTATGPQGA PGEGPPTHFP TPPGVMSPDM QNASLNQPPC PGGPPMMGNF GPGDGPPHPG
IGPPGPPSEG NFFNNFFKQQ DDMKMDGVVQ EGDGYHGFAG MDEREGSGLF GHQADGQESS
ANGSSASQGG ISVPDFLPPA QRVLFMRIQQ KQQEEEERAR RIAEGGTEKI KETEGDSGNW
YSSEDEDGGG SVTSILKTLR QQTQVPHKPD GPPSDPRLQK APPVLTRPAD PRLARDPRLA
RATESAQNSE SAHSGSVPPP SGPPADPRLA RLTAAASSGS TSLSPPGPKQ EPPLVYKPPP
LTAPAAEEEE TERVLREKPV PIPLDPLMGM ALRDPRSQLQ QYSHIKKDVV LHMPAFCKTI
TWSPEDLLPL PIPKQDFLPL PPGVPPASTI DPRLSRAQQS LHTPVPHSQP PAAHPPASLD
APAPSSSNSS LPDFELLSRI LKTVNSSPSQ TPSPPLPTPT VPVSTLGSAP PPLPAEKPID
PRVARKDPRL QPQKSALKQP SEAAPFAASS TSSSTPSSSS SPSIAPYDPR LLSSGGAACS
VSAGSPGGAS VLSSISLYDP RTNKPGSPST SSGSNNSPNS TSSESKPSDT TTGKPKHKEP
LFVRKSALDQ PEMEKTGDQG TDRYNSYNRP RPKPAHSPNS TVQGGAATAV GGAAGGAGPG
SAADQGPAGV HNLPVTSLFG VAKVSKPGGT GSPFGGNSPV QPDQAATEQD KASLKDVFKG
FDPTASPFCQ
//
