ID H2T4I6_TAKRU Unreviewed; 762 AA.
AC H2T4I6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
GN Name=itgb8 {ECO:0000313|Ensembl:ENSTRUP00000019574.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019574.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019574.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019574.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR AlphaFoldDB; H2T4I6; -.
DR STRING; 31033.ENSTRUP00000019573; -.
DR Ensembl; ENSTRUT00000019654.3; ENSTRUP00000019574.3; ENSTRUG00000007871.3.
DR eggNOG; KOG1226; Eukaryota.
DR GeneTree; ENSGT01090000259987; -.
DR TreeFam; TF105392; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 2.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR033760; Integrin_beta_N.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF9; INTEGRIN BETA-8; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR Pfam; PF17205; PSI_integrin; 1.
DR PIRSF; PIRSF002512; Integrin_B; 2.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SMART; SM00423; PSI; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..762
FT /note="Integrin beta"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025557482"
FT TRANSMEM 673..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..80
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 39..427
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 590..672
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT REGION 441..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 32..427
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 40..50
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 43..79
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 53..68
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 195..202
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 250..291
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 364..375
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 395..636
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 425..429
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 443..477
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 483..488
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 485..518
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 490..503
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 524..529
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 531..540
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 542..549
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 563..568
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 565..613
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 570..580
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 583..586
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 590..599
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 596..667
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 617..644
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
SQ SEQUENCE 762 AA; 83006 MW; 3FF0BB95AB9D913A CRC64;
MTTWLRSVPL CVLLYSALSL CAQDHGAGGA MCLSASITSC AECLSHGPQC AWCFKEDFLN
GADLGWRCDL PENLLNRGCE AESMERWETK VVVNTTISST QVSPGDISIT LTPGSEASVV
VAVKQLQRYP VDLYYLVDVS ASMQENLNHL KTVGVALTLR MTEHSSDLWL GFGSFVDKPV
SPYIDVHPSK INNPCSDYEI RCRPAHGFHH VLSMTGNMSE FTRVIKRQHI SGNMDTPEGG
LDAMLQAAVC QEAVGWRSEA KRLLLLMTDQ PSHLALDSRL AGIVVPHDGL CHLENNVYTG
STRMDHPSVG QLSDKLLENH IYSVFAVEKQ QYQWYERLLS EVEVSISVED KAVDRYSVSV
SPICPEGSTL KGQSCSGVQP NQTTYFKITF GLRSCPDDGG DEDVTVLIHP VGYNESTVVR
IHSKCVCSCG VTKRCSNDGQ SPCSGMQDED RGPNHELMDS NKGSNRNCRP DVADVDCSGR
GVCECGRCVC DRSKLGAVYG KYCEIDDFSC PYHEGLSCGG RGACVSSECV CTDGWTGESC
SCPISTATCQ SASGSLCSGR GRCVCGKCAC DDPQYSGDFC ETCPACQSPC QSHWKCVDCH
LSHGLAPKEA GHCNSTCIPL VGYVDDTSGH VGGVQCMYIN NDSCRYQFQT RSQYGQAMLY
ISTRPECASS SRMVGTFLSV CALTVLCGLV VVAFSRLLLQ KRIRTPAGAG EDGVFHCTGK
DLSYIPTTNE KTVTYRRDNP PDHSLEMHIQ VPKMPLGDPW QF
//
