ID H2T4R5_TAKRU Unreviewed; 866 AA.
AC H2T4R5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Period circadian protein homolog 2 {ECO:0000256|ARBA:ARBA00039684};
DE AltName: Full=Circadian clock protein PERIOD 2 {ECO:0000256|ARBA:ARBA00042893};
GN Name=LOC101061913 {ECO:0000313|Ensembl:ENSTRUP00000019653.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019653.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019653.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019653.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; H2T4R5; -.
DR STRING; 31033.ENSTRUP00000066372; -.
DR Ensembl; ENSTRUT00000019733.3; ENSTRUP00000019653.3; ENSTRUG00000007894.3.
DR GeneTree; ENSGT00940000156342; -.
DR HOGENOM; CLU_006667_0_0_1; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR048814; Per1-3_PAS-A.
DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1.
DR PANTHER; PTHR11269:SF9; PERIOD CIRCADIAN PROTEIN HOMOLOG 2; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF21353; Per3-like_PAS-A; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 423..466
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 18..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 94894 MW; 8CA2A4E4B72E767C CRC64;
MSEHSDSKPF LFTVLEDEGE ASGCRGATSC SALPRGGSAG PHLGLQSEGS DSSGQDPPAS
PHTHRKTGRS RALTEDEVEM KSSGSSGSGT ESHSNESHGN ESHGNESHGN ESHGNESNGH
ESVSSSNGNS KDSALLESSG SNKSSDSHSP SPPSSSNAFS LLSSEQDNPS TSGCSSEESA
KAKTQKEVIK TLKELKLHLP AEKRHGYKSS TLSTLKYALR CVKQVEANEE YFQLQRINDS
HPSGLDVSSY TIEEIDSITS EYTLKNNDIF AVAVSLSTGR IVYISDQAAS ILNCRRDVFK
NTKFVEFLAP QDVSVFYSFT TPYRLPSWSM STGAESSPSD CVQEKSFFCR ISGGKECRGD
LQYYPFRMTP YLMKVQDTVH AEDQFCCLLL AERVHSGYDA PRIPTDKRIF TTTHTPSCVF
QDVDERAVPL LGYLPQDLIG TPVLLHLHPN DRPVMLGIHR KILHYAGQPF DHSSIRFCAR
NGEYIILDTS WSSFVNPWSR KVSFVIGRHK VRMGPVNEDV FVAPTSAAEV KTVDSDIQEV
TEQIHRLLLQ PVHTSGSSGY SSLPRTDHIF SMTSSSEDNC CGDKMPEQEE ETCSKSRPRT
FQEICKGVHL QKNQEQQANK ADNKKNKRSP AVVRPKDSAA LLNPREPGAA VEESRPSSFQ
EMTFNEQTIY SYQQISCLDS VVRYLESCSV PISMKRRCRS SSNTTSSNSD DCKQKGSGQV
QVSAGDQSGL LPLDVPDKKS GDAAVVGTSL PLPVPNKPES VVSITSQCSY SSTIVHVGDK
KPQPDSGTFS CAPPPLAVSP PSQEREAYKK LGLTKQVLAA HTQKEEQAFL YRFRKLRGLS
SLKANCSPVS MYLERQREQI NSNATC
//
