ID H2T9G3_TAKRU Unreviewed; 1267 AA.
AC H2T9G3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=LOC101074687 {ECO:0000313|Ensembl:ENSTRUP00000021303.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000021303.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000021303.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000021303.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR AlphaFoldDB; H2T9G3; -.
DR Ensembl; ENSTRUT00000021391.3; ENSTRUP00000021303.3; ENSTRUG00000008503.3.
DR GeneTree; ENSGT00940000154695; -.
DR HOGENOM; CLU_003384_0_1_1; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR CDD; cd12092; TM_ErbB4; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF90; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transferase {ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 615..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 681..948
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1054..1102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1089
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 806
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 687..695
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 714
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1267 AA; 141478 MW; FDF48F97130ECADE CRC64;
MMCAGTENKL STLSDLDQQY QTMRKNYENC EVVMGNLEIT SIDRSRNLTF LRSIREVTGY
VLVALNQFDY LPLENLRIIR GTKLYEDRYA LAIFLNYRRD GNSGLRQLGL KNLTEILNGG
VYVDRNNFLC HADTIHWQDI VKHPRIHPLV VPTNSSITCQ KCHRSCNGRC WGPKVDQCQS
LTKTVCAEQC DGRCFGPYIS DCCHRECAGG CYGPKDTDCF ACTNFNDSGA CVTQCPQPFF
YNSITFQLEH NVRTKYTYGA FCVKKCPHNF VVDHSSCVRA CPSNKMEVEE NGIKICIPCT
DICPKACDGI GTASLQTAQT VDSSNIDKFV NCTKINGNLV FLITGIKGDS YHNIEALDPE
KLNVFRTVRE ITGFLNIQSW PDNMTDLSVF SNLATIGGRT LYSGISLLVL KQQGISSLQL
QSLREISAGN VHVADNSQLC YYNTINWTRL FRTAHQKALI RNNQSPEQCS KKRMVCDPLC
SGAGCWGPGP DQCLSCKYFS RGRTCVDGCN LYEGEIREYA NESVCVECDG QCELADDDSL
TCHGPGPEHC EKCLHFKDGP NCVEKCPDGL QGANSFIFKY AEANNECHPC HANCTQGCIG
PRLQDCIGLM DRTPLIAAGV IGVLFMVVIL VLSVAVSVRR KNIKKKRALR RFLETELVEP
LTPSGTAPNQ AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGEKVKIP VAVKILNEAT
GPKANVEFMD EALIMASMEH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS
QLLLNWCVQI AKGMMYLEER RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDVNEKEYNA
DGGKMAIKWM ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGISTR DIPDLLEKGE
RLPQPPICTI DVYMVMVKCW MIDADSRPKF KELAAEFTRM ARDPQRYLVI QGDDCMKLPG
PNDSKFFQSL LAEEELEDLM DAEEYLVPHS FNIPPLAYTP RTRMDSNKNQ FGYQDPSFSM
EKMLATLPRG VSGASVSGGC LPTQDLASGV QVGGGFIRSN QDDPRCNGTL KKQASPRTDD
SSGQRYSADP TGLLSERGAK GDQDGYMAAM RDKKISVEEN PFVTRRRNGD AHAVMDGAGC
HTLHIAAAAA APKNQHIHGD DEYINEPLYL NTFLNPGDKN GLTASNTIMK NKKANFDNPE
YWQHSLPPKS SLHNPEYLQD CSTRFFYRQN GRIRPAVAEN QEYLSEAAMK AGNVLPPPPY
RQRNTVV
//