ID H2TBS3_TAKRU Unreviewed; 519 AA.
AC H2TBS3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=von Willebrand factor A domain-containing protein 1 {ECO:0000256|ARBA:ARBA00029542};
GN Name=LOC101078223 {ECO:0000313|Ensembl:ENSTRUP00000022115.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000022115.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000022115.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000022115.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
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DR AlphaFoldDB; H2TBS3; -.
DR STRING; 31033.ENSTRUP00000022115; -.
DR Ensembl; ENSTRUT00000022205.3; ENSTRUP00000022115.3; ENSTRUG00000008802.3.
DR GeneTree; ENSGT00940000160734; -.
DR HOGENOM; CLU_042926_0_0_1; -.
DR InParanoid; H2TBS3; -.
DR OMA; PPVEDHL; -.
DR OrthoDB; 3087119at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR GO; GO:0061035; P:regulation of cartilage development; IEA:Ensembl.
DR GO; GO:0051124; P:synaptic assembly at neuromuscular junction; IEA:Ensembl.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF77; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..519
FT /note="von Willebrand factor A domain-containing protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025509105"
FT DOMAIN 37..214
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 219..327
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 330..420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 422..511
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 519 AA; 56085 MW; 681A5B6D07734811 CRC64;
MLERHACLTW MLLCVLVRQA SGQNHAPEGV LNCCEGDVLF LLDSSGSVSS YEHSRMLTFL
SELLQPFSLG EGQVRVGLLQ VGSQPRLEFG FDTHGTQSGL QESLRNTKPL RGDTKTVEAL
KIAKERVLRP GVPGGAREGL PRVLVWLTDG VNPGDVMGPM AELQQEGIAV LVVSTGHSNY
LVMREVVTPP LENHLYFVDI DDMSIITDDL RDAIIEIIRA ERINIHDIST NSATVQWRPV
LSGLRGYYEV RFGPLVTQVP GGGGGAETGT SPSTGGSQYQ RLVQPADSST ARLTGLKPDT
TYTVTLIPES NEHSFNALTA TFTTKPEVLS PSVVTVTESG ATSVRLSWGP LQPQTVTSYY
IEYSALPRGE LRTATVHRTQ NSTLLTDLQP GTTYLVTITA RYASGKGKAM SVKACTEEET
PALADLQLTT VGSDAVQVNW KVSEGGPSGY LLTWEGQQSS ATGQRSTVYL PPDSQTTRLT
NLPPSARVCV SPIYHTGRGD GLCCTANFHP DLLTYGYQS
//
