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Database: UniProt
Entry: H2TDW3_TAKRU
LinkDB: H2TDW3_TAKRU
Original site: H2TDW3_TAKRU 
ID   H2TDW3_TAKRU            Unreviewed;       418 AA.
AC   H2TDW3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   10-APR-2019, entry version 40.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=LOC101068133 {ECO:0000313|Ensembl:ENSTRUP00000022855};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000022855, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000022855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000022855}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   STRING; 31033.ENSTRUP00000022855; -.
DR   Ensembl; ENSTRUT00000022950; ENSTRUP00000022855; ENSTRUG00000009093.
DR   eggNOG; ENOG410IH0U; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H2TDW3; -.
DR   OMA; FPACGNG; -.
DR   TreeFam; TF321598; -.
DR   Proteomes; UP000005226; Chromosome 3.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR027260; Hyaluronidase-3.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   PANTHER; PTHR11769:SF19; PTHR11769:SF19; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 2.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    418       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017281294.
FT   DOMAIN      362    413       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   ACT_SITE    132    132       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID     45    341       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    208    224       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    366    377       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    371    401       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    403    412       {ECO:0000256|PIRSR:PIRSR038193-3,
FT                                ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   418 AA;  46986 MW;  E351AED629E53B56 CRC64;
     SFLAGFPLVL ILACVIISTG TTAAAGPILL DRPFVVVWNI PTARCQQHYN VHLDLRDFDI
     VENRQQDFRG QKMTIFYRDH LGMYPFISRE GWKVNGGIPQ LGCLSAHLSL AESQISRLLW
     ANFTGLAVID WEEWQPLWEK NFGTKMEYRR LSKLLVRQER PGLSDKDVAS LARQRFEASA
     RKFMEGTLQT AISTRPKGLW GFYGFPVCSN KHKRKTDHSY TGRCHTGTKR QNDRLSWLWG
     QSTALYPSIY LPQSLAGSSR AALMVRYTLL EALRVASLWR HGGTSSGATP VLPYARLAYT
     HSLAFLNKTD LLHTLGESAA LGAAGVVLWG EMKFAKSEHQ CILLRDYIHG VLGPFIRALR
     ADTQLCSLRL CHSNGRCTSR HLGSGHTFSS GPALTSKHFK CQCYLGWTGQ NCQEKIRP
//
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