ID H2TEJ7_TAKRU Unreviewed; 599 AA.
AC H2TEJ7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Nuclear receptor subfamily 1 group D member 2 {ECO:0000313|Ensembl:ENSTRUP00000023090.3};
DE SubName: Full=Reverse erythroblastosis virus beta {ECO:0000313|EMBL:BCA77645.1};
GN Name=LOC445936 {ECO:0000313|Ensembl:ENSTRUP00000023090.3};
GN Synonyms=Rev-erb beta {ECO:0000313|EMBL:BCA77645.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023090.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000023090.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|EMBL:BCA77645.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BCA77645.1};
RA Tsutsui Y., Onoue T., Kono T.;
RT "Circadian expression of CC chemokine ligands in the Japanese pufferfish
RT (Takifugu rubripes).";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000023090.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR EMBL; LC522349; BCA77645.1; -; mRNA.
DR RefSeq; XP_003965743.1; XM_003965694.2.
DR STRING; 31033.ENSTRUP00000023090; -.
DR Ensembl; ENSTRUT00000023186.3; ENSTRUP00000023090.3; ENSTRUG00000009180.3.
DR GeneID; 445936; -.
DR KEGG; tru:445936; -.
DR eggNOG; KOG4846; Eukaryota.
DR GeneTree; ENSGT00940000155168; -.
DR OMA; NHGEESA; -.
DR OrthoDB; 3475284at2759; -.
DR TreeFam; TF328382; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR CDD; cd07166; NR_DBD_REV_ERB; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001728; ThyrH_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR45805; NUCLEAR HORMONE RECEPTOR HR3-RELATED; 1.
DR PANTHER; PTHR45805:SF7; RAR-RELATED ORPHAN RECEPTOR C B-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00546; THYROIDHORMR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 95..171
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 337..599
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 20..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 65454 MW; 9CD1F40C15C97AD5 CRC64;
MPEDVGTAKA GGVIAYISSG STSIPESCRS GSPNSSYLST SPSLSRPALP SRAIGMVVDI
SPPTKSSQQR SHGVEKPGRS SSSSKTCVTK INGMVLLCKV CGDVASGFHY GVHACEGCKG
FFRRSIQQNI QYKKCLKMEN CTIVRINRNR CQQCRFKKCL AVGMSRDAVR FGRIPKREKQ
RMLLEMQNAM NNMMSNNSQL HTMLHSHQSP SPPMEASDAS SAPSSSSSSS SSSSSFSASD
SSSCSSPSSP QCPQDSESVI SMDTNSSSAS SCASDSGEDE AVVTGSGQRQ NAFAYRQQSQ
ASYSLVTVPT EAGCMEVPAE QENWNCWNKN TGVEAYQYRS HSPHVSNAAY REERGDYQQQ
CHSAPSRKPA EDAKSWREFK RLPSCRGPQE PNSCLHNRTR LVCPMNTSPY VGPNKSSQEI
WEEFSMSFTP AVQEVVDFAK RIPGFRDLPK NDQVSLLKAG TFEVLMVRFA SLFNAAERTV
TFLSGKRYSL DTLCSLGAGE LLLSMCEFSE KLAALRLDSD EMSLFAAVVL VSADRSGIQD
LNAVEALQDQ LIRALRNLIG EKHGDESATT FTKLLLKLPE LRSLNNLHSE ELLSFKVHP
//
