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Database: UniProt
Entry: H2TEY2_TAKRU
LinkDB: H2TEY2_TAKRU
Original site: H2TEY2_TAKRU 
ID   H2TEY2_TAKRU            Unreviewed;       884 AA.
AC   H2TEY2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   08-MAY-2019, entry version 48.
DE   RecName: Full=Neuropilin {ECO:0000256|PIRNR:PIRNR036960};
GN   Name=nrp2 {ECO:0000313|Ensembl:ENSTRUP00000023225};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023225, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000023225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000023225}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the neuropilin family.
CC       {ECO:0000256|PIRNR:PIRNR036960}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   Ensembl; ENSTRUT00000023322; ENSTRUP00000023225; ENSTRUG00000009236.
DR   GeneTree; ENSGT00940000155270; -.
DR   Proteomes; UP000005226; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00057; FA58C; 2.
DR   CDD; cd06263; MAM; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   InterPro; IPR014648; Neuropilin.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   Pfam; PF00629; MAM; 1.
DR   PIRSF; PIRSF036960; Neuropilin; 1.
DR   PRINTS; PR00020; MAMDOMAIN.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00231; FA58C; 2.
DR   SMART; SM00137; MAM; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01285; FA58C_1; 2.
DR   PROSITE; PS01286; FA58C_2; 2.
DR   PROSITE; PS50022; FA58C_3; 2.
DR   PROSITE; PS50060; MAM_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|PIRSR:PIRSR036960-
KW   1}; Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR036960};
KW   Differentiation {ECO:0000256|PIRNR:PIRNR036960};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR036960-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00059, ECO:0000256|SAAS:SAAS01008102};
KW   Membrane {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036960-1};
KW   Neurogenesis {ECO:0000256|PIRNR:PIRNR036960};
KW   Receptor {ECO:0000256|PIRNR:PIRNR036960};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    884       Neuropilin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017217309.
FT   TRANSMEM    805    828       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       28    142       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      149    267       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      277    427       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      434    594       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      634    782       MAM. {ECO:0000259|PROSITE:PS50060}.
FT   METAL       197    197       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   METAL       211    211       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   METAL       252    252       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   DISULFID     28     55       {ECO:0000256|PIRSR:PIRSR036960-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID     83    105       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    149    175       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    208    230       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    277    427       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    434    594       {ECO:0000256|PIRSR:PIRSR036960-2}.
SQ   SEQUENCE   884 AA;  98205 MW;  68DE93A7DCF78643 CRC64;
     MDFVSLAGFL VTICQLALQI RGEEVAECGG VLDASKAGYI TSPGYPLEYP PHQNCHWVIT
     APEPSQRIVL NFNPHFEIER LDCKYDFIEI RDGTSDTADV LGRHCSNIAP APIISSGSSL
     QIRFVSDYAH QGAGFSLRYE IFKTGSEFCF RNFTSPSGMI ESPGFPDKYP HNLECSYMII
     APPHMDIMLT FLTFDLENDP LLVGEGDCKY DWLDVWDGLP QVAPLIGRYC GTKIPPEIQS
     SSGLLSLSFH TDMAVAKDGF SARYNLTRKE VSDSFHCSTT LGMESGRISD DQISASTTFY
     DNRWLPRQAR LNNNDNAWTP SEDSNKEYIQ VDLQFLKVLT GIATQGAISK ETQKSYYVTT
     FKLEVSTNGE DWMVYRHGKN HKIFHANTDP AEVVLNRVPQ PVLARFVRIR PQAWKNGIAL
     RFELYGCQIT DAPCSDLQGM LSGLLPDTQI SASSSRDMVW NPGTARLVAS RSGWFPGPAQ
     PLAGEEWLQV DLGVPKMVRG VITQGARGGD AGSGATTDNR AFVRKYKVAH SLNAKDWNFI
     MDSKFSLPKI FEGNTHYDTP ELRHFDEVVA QYVRLYPERW SPAGIGMRVE ILGCDLPETT
     TPAFSTTPTV PAESTTVPIT TTAATVSTSP SSDGVCDFDH GLCGWTHDPN APLFWSLYSH
     ELNSYLYMDA SLKTEQQRAR LVSPLVAADT GPLCLTFSYQ LWGEAQGHLR VLLRDNHNEE
     TVLWTLKDDQ GPVWKEGRTI LPRSPKDFQV VMEGFFAHGT RGHIWIDNIH MSLSTPLTEC
     TQPFAAFSPE NPGGGVPVPP LPIHWYYIMA AGGALLLLAV AILVRALCCC RQHLATKKSQ
     LSVAYHSSSQ CFQYSNWSSS MATPGVEPVL TVRLDSRDRH RTLC
//
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