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Database: UniProt
Entry: H2TFA6_TAKRU
LinkDB: H2TFA6_TAKRU
Original site: H2TFA6_TAKRU 
ID   H2TFA6_TAKRU            Unreviewed;      1872 AA.
AC   H2TFA6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 43.
DE   SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit a {ECO:0000313|Ensembl:ENSTRUP00000023352};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023352, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000023352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000023352}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   Ensembl; ENSTRUT00000023449; ENSTRUP00000023352; ENSTRUG00000009289.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     93    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    131    152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    164    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    224    243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    329    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    522    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    617    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    694    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1130   1148       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1197   1215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1261   1283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1373   1398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1454   1473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1485   1507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1576   1601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1667   1691       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1842   1871       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      725    745       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1872 AA;  213382 MW;  965FD93C48985B7A CRC64;
     MARFGDDVPG LLSSGDGGSD RIRNRDGAAV STGGISPAFK QTKAQRARTM ALYNPIPVRE
     NCFTVNRSLF FGEDNVVRKY AKKITEWPWS TPFEYMILTT IIANCIVLAL EQHLPGEDKT
     PMSKRLEKTE PYFIGMFCFE AGIKIIALGF VFHKGSYLRN GWNVMDFIVV LSGWILAAAG
     AHMNISVDLR TLRAVRVLRP LKLVSGIPSL QIVLKSIMKA MVPLLQIGLL LFFAILMFAI
     IGLEFYSGRL HSTCENETVD STELEFPCGV RQCPTGYLCS NAWIGPNDGI TQFDNILFAV
     LTVFQCITME GWTTVLYNTD DALGPLWNWL YFIPLIIIGS FFVLNLVLGV LSGEFAKERE
     RVENRRAFMK LRRQQQIERE LNGYRAWIDR AEEVMLAEEN KNAGPSALDG KWYLRRPVLK
     RATTIKRRGM DVVHRGQPGE EQYGDISSVV PSGIPMARAS IRSARRGPTA YFRRKERLLR
     ISIRRVVKTQ TFYWTVLGLV ALNTLCVAIV HHNQPRWLSS FLYYAEFLFL ALFLTEMFLK
     MYSLGPRLYF HSSFNCFDCS VIVGSIFEVL WGFFRPGTSF GISVLRALRL LRIFKITKYW
     ASLRNLVVSL MNSMKSIISL IFLLFLFIVV FALLGMQLFG GRFIFEDYTP TNFDTFPAAI
     MTVFQILTGE DWNEVMYDGI RSQGGVKSGM WSSIYFIVLT LFGNYTLLNV FLAIAVDNLA
     NAQELTKDEE EAEAAFNEKH ALQKAKEVGP LSSFMSSDVC SIKKERDAAC RSHPTSSLIR
     SRRERRKRMT MSVWEQRTSQ LRRHRQMSSR EILFTNPTEE KDGPPASAQG RSLSLHRKVL
     ENMPSVDIPV HADIPEPPES VVTKESLEST NMPLPDASES NPCGANLDDS QTHNTASGRQ
     NPRLHGDRQH RAVKKFRPPD KPESLTPEMG DHDRIKGRRA LHRRDHQNET WNQGSSNGNG
     NHLASRSVSR ERKRNSGKLD EAEINTVEEK SGDHESRCLT RGDKSEGGDS GAAKNQNHTS
     DQSPQTQEEP PQQVEPTDVS ETNKEESETE QEGGSCQLSS SVIVDMPNVQ SSMELSTLTV
     NSKDPETCKS EKEELEEVNP ANSVIPNSMF IFKHDNPVRR VCHYVVNLRY FEMSILLVIA
     ASSIALAAED PVATSSDWNK VLRYFDYVFT GVFTFEMIIK MIDQGLILHD GSYFRDLWNI
     LDFIVVVGAL VAFALSNNKG RDIKTIKSLR VLRVLRPLKT IKRLPKLKAV FDCVVTSLKN
     VFNILIVYKL FMFIFAVIAV QLFKGKFFYC TDSSKDTEKE CQGYYIDYGK DKKEMKRREW
     RRHEFHYDNV MWALLTLFTV SSGEGWPQVL QHSVDVTEED RGPSHGNRME MSIFYVIYFV
     VFPFFFVNIF VALIIITFQE QGDKMMEECS LEKNERACID FAISAKPLTR YMPQNRHTFQ
     YRLWHFVVSP SFEYTVLAMI ALNTIVLMMK YYSAPPAYEA VLKHLNTAFT VIFSVECILK
     IMAFGLLNYF RDTWNIFDFI TVLGSITEII VDLQSVEKFN MSFLKLFRAA RLIKLLRQGY
     TIRILLWTFI QSFKALPYVC LLIAMLFFIY AIIGMQVFGN IKLSDKTHIN QHNNFKTFSG
     ALLLLFRSAT GESWQEIMLS CLGGQKCETD MAVPASDPEG GCGSDFAYFY FVSFIFFSSF
     LMLNLFVAVI MDNFEYLTRD SSILGPHHLD EFVRIWGEYD RAARGRIHYT DMYEMLTNMS
     PPLGLGKKCP SKLAYKRLVL MNMPVDEDMS VHFTSTLMAL IRTALDVKIA RGGEDRNQMD
     LDLQKEIGVI WPHLSQKSLD LLVPIHKGDG SVHSKFLSPF SASDMTIGKI YAAMMIMDYY
     KQSKAKKLRQ QL
//
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