ID H2TFZ4_TAKRU Unreviewed; 1173 AA.
AC H2TFZ4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Probable G-protein coupled receptor 158 {ECO:0000313|Ensembl:ENSTRUP00000023592.3};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSTRUP00000023592.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023592.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000023592.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000023592.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; H2TFZ4; -.
DR Ensembl; ENSTRUT00000023690.3; ENSTRUP00000023592.3; ENSTRUG00000009386.3.
DR GeneTree; ENSGT00940000155918; -.
DR HOGENOM; CLU_006832_1_0_1; -.
DR Proteomes; UP000005226; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF11; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1173
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025561904"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 393..643
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 26..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..923
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 130520 MW; A9BBF11CCA246AEC CRC64;
MAVFRLSLLL QVALVIGSNL RYPERSAHRG EGTREAADRA QAQRRRLHHP PAVTAELPQK
LEERLPKVVA AFLHSGDSTT LQHANCSGRY ELTSLRGRSH AVPHRSMSGA LDAVLHATNF
LNMILQANRS REQSLRRDIE WYHALVRSIL EGDSKIHRAV VTFGADASAE GPAVLLQATR
AGGEIVLQDL SSVAHRLHNR TADTGWYHDV KDAKKKPGFR KRVLSQDLRS AENSVKRGES
FIPDRSHVRW SAPYLECHNG NFVPRWLLTL SAAFYGLKKD LAPVFSGVVR VDISLQDVDI
DQCSSDGWFG GTHRCNTTTM ECLPIHGHGF VLDKYSCHCK TGFYHPSRLA VNSFAKSGPN
ADEGSSSDCL PCQQGCAYCK DDTPCVAQED GALRLAVLSF QCLCLLAILL SMVLVYHFRR
NKSIRASGLV LLEAILCGAL LLYFPVGILY FQPSVFRCIL LRWVRLLGFA TVYGTLTLKL
YRVLKVFLSR TAQRIPYMTS WRVLRLLGII LLIVCWFLVA WTSAVCEHPD RKSALIDVGY
TPDGLQFSMC LLDRWDYMMA VAEFLFLLWS VYLCYAVRTV PSAFHEPRYM AIAVHNELVL
SAIFYIIRFT LVQELHPDWM LLLFFTHTHL TVTVTLGLLL IPKFLFAGTH MRDDIASEAY
EDELDMGRSG SYLNSSITSA WSEHSLDPED IREELKKLYS QLEVYKRKKM LANNPHLPKK
RSSKKGLGRS LMRRITEIPE SVHRQCSRED KEAGEHASNR NSICALKKNP FDPTHAGKPA
KEETLKSKVF SLKKSHSSYD HVRDQREDSD SSATDKMEVA TAEGSLLDTL MGKKVVKKSS
ENISAPSEST ESVPLVCKSA SAHNLSADKK PIHGRASMLQ KSLSVIASAK EKTLGLTAKA
QSSEDSNKKS QPKSKDPRAS VEPDYEAPPK TLVSQVVEGK QNTTKGRVVK QLATGHQPTC
SDLVKGKDLY DLSEVCPWEV EDLPTPSENK VQKHVSIAPK ETTTVHGGST KGSKAQQHKQ
KGSDQSPSIG RHSAEAQKTA AARAEVCPWE DENKSQGSQV DPSKQQTLIQ ASRPTTTQQP
QPATDTFKTS RVEVCPWDFQ EPQKTVEQRK GTSPVEAKAR SVLTDPSRPG GSLQLQPARA
DVCPWEYDNT TVSPNSGQRT PSPSQASKAK EIW
//
