ID H2TH44_TAKRU Unreviewed; 549 AA.
AC H2TH44;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Nuclear receptor subfamily 5, group A, member 2 {ECO:0000313|Ensembl:ENSTRUP00000023993.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023993.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000023993.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000023993.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily. {ECO:0000256|ARBA:ARBA00007536}.
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DR AlphaFoldDB; H2TH44; -.
DR Ensembl; ENSTRUT00000024092.3; ENSTRUP00000023993.3; ENSTRUG00000009548.3.
DR GeneTree; ENSGT00940000153391; -.
DR InParanoid; H2TH44; -.
DR OMA; DNMQVSQ; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0061017; P:hepatoblast differentiation; IEA:Ensembl.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd07069; NR_LBD_Lrh-1; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086:SF49; NR5A2 PROTEIN; 1.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 87..162
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 308..547
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 429..432
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 524
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 528
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
SQ SEQUENCE 549 AA; 61946 MW; EBD1578686513972 CRC64;
MRRRGRRGLH ISRQSDTPNS TLRAGEGGPV RAYSPSPAQA GSADMLPKVE TESLGLSRSY
GEQGLMPRNM QAHQLKMMDY SYDEDLDEMC PVCGDKVSGY HYGLLTCESC KGFFKRTVQN
NKRYTCIENQ SCQIDKTQRK RCPYCRFQKC LTVGMKLEAV RADRMRGGRN KFGPMYKRDR
ALKQQKKALI RANGLKIEAM TQVMQAVPTD LTISSAIQNI HSAASKGLPL SHHGGHHGDY
DRSPFVTSPV SMAMPPHAGS LQGYQTAYGH FQGTRTIKSE YPDPYTSSPE SIMGYAYVDA
YQTGSPPSFP HLIVELLKCE PDEPQVQAKI LAYLQQEQAS RGKHEKLNTF GLMCKMADQT
LFSIVEWARS SIFFRELKVD DQMKLLQNCW SELLILDHVF RQVVHAKEGS ILLVTGQQVD
FGVIASQAGA TLNNLLSHAQ ELVGKLRSLQ LDQREFVCLK FLVLFSLDVK NLENFHLVES
VQEQVNAALL DYVMCNYPQQ TDKFGQLLLR LPEIRAISLQ AEEYLYYKHL NGDVPCNNLL
IEMLHAKRA
//
