ID H2TJR1_TAKRU Unreviewed; 1201 AA.
AC H2TJR1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Immunoglobulin superfamily DCC subclass member 4 {ECO:0000313|Ensembl:ENSTRUP00000024915.3};
GN Name=IGDCC4 {ECO:0000313|Ensembl:ENSTRUP00000024915.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000024915.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000024915.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000024915.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2TJR1; -.
DR STRING; 31033.ENSTRUP00000070676; -.
DR Ensembl; ENSTRUT00000025018.3; ENSTRUP00000024915.3; ENSTRUG00000009917.3.
DR eggNOG; KOG4221; Eukaryota.
DR GeneTree; ENSGT00940000159637; -.
DR TreeFam; TF321506; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1201
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025341824"
FT TRANSMEM 923..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 129..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..307
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 317..403
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 413..507
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..606
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 618..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 724..817
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 997..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1063
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 130052 MW; BB081997466E70D4 CRC64;
MALESPIRLF CLLWLLCGPS KQETIVSVEL SCGGGPSHVV LEPGLPLLLD CNLGATEAPF
NVTWLQDGQP LPLEGGDFVQ YLDNGSLLLQ PSQDGKPPPG VEGAYSCVTA SALGALTSRT
VNVLVASLSR FHHEPSPQTV LIGGAARFEC QIEGVPTPTI TWEKDRMAVP EETSRFISLP
NGVLQILRVT KKDEGAYRCV VSNSARKDVS LEAKLTVSTE PTANPNRVVI VAPPRNTTVM
LGRPAVMECM AEGQPKPLVS WSRQDGKPIS TDVVVLATNL VIRDTRSHHA GVYVCRANKP
KTREFITAAA ELHVPAPPLI VQPPETASLS RGNTARFVCN STGEPSPVLH WLKDGQPIKS
FRRVKSQSPG ILLINQLALE DAGYYQCIAD NGLGTACATA KLTVIVREGL PSAPQHVTAT
PYSSTSALLA WEKPEHNSDQ IIGYSVHYQR ATGADNVEYQ FAMNNDTTEY LVKELAPHTA
YTFFVVAYSP MGASRPSVPV TIEMMEDVPS APPQLAIASS SPTEIRLMWH PLPSERSRGT
VTHYRIEYST MEQADSVFSV EVGGNETQFT LSELEPNQLY RVRIAAGTGI GFGVPSDWVQ
HQTLARYDHS DHSILIFAPT ELKVRAHMNT LNVTWQPSPN HTLASGYKLS YREVDAAESA
KTHTVRLRKK ARYHLLTGMV PNRQYEVKVW AFSKQVDGAV AVWKGRTEKA HVRPSPLPMP
PPLPPGSIQA MANSSTSIWL RWEKPRFSNV RIINYTVRCS PAGTTNASLV SYHTSAAQEI
LLGALKPFTR YELAVQSNGV DVVGPFSDTV EEATLSDRPS TPPEELQLNA LDSSSVLVSW
RPPLEPNGII ISYWILYSGN LSQPDHLWEK LSQEGSITSV EVQGLSSGSH YFFKLGAATE
VGPGPYSPVK DIRTPLPKYE LDVHAVTGII VGVCLGLICI LLCMCLSFRS NKTREVAGGL
VPTAGNTHYK RGGSPVLPSL PECIDSHELE TLMSADKGES AHLPDEASEE QRLMPSAPGD
EEEIPPTEPK DSVDHLCSNR VEAEVIVHSE LSDAGKEKAE EAAGKGNGSF TPRGPSLSES
TYSPLREQIP PGEKETAGKV AHGPASVPSI KSVANHNGEL EARGVQLSSE LELPKDTGLT
NGFHSPKDMC SMLRSDHLES RDSRQCPLAP GKVISGGLPP TPFVSSGLVH STSAAHTYLC
P
//
