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Database: UniProt
Entry: H2TJZ1_TAKRU
LinkDB: H2TJZ1_TAKRU
Original site: H2TJZ1_TAKRU 
ID   H2TJZ1_TAKRU            Unreviewed;      2716 AA.
AC   H2TJZ1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000024995};
GN   Name=LOC101074739 {ECO:0000313|Ensembl:ENSTRUP00000024995};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000024995, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000024995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000024995}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   RefSeq; XP_011612036.1; XM_011613734.1.
DR   Ensembl; ENSTRUT00000025098; ENSTRUP00000024995; ENSTRUG00000009941.
DR   GeneID; 101074739; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000005226; Chromosome 19.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2237   2259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2271   2289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2317   2335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2355   2382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2403   2425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2537   2560       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED     1590   1610       {ECO:0000256|SAM:Coils}.
FT   COILED     2084   2104       {ECO:0000256|SAM:Coils}.
FT   COILED     2647   2695       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2716 AA;  309801 MW;  8992D766599AF72A CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGG NTDAVLLNKL HHAADLEKKQ NDSENKKLLG TVIQYGNVIQ
     LLHLKSNKYL TVNKRLPALL EKNAMRVMLD TAGNEGSWFY IQPFYKLRSI GDSVVIGDKV
     VLNPVNAGQP LHASTHQLVD NPGCNEVNSV NCNTSWKIVL FMKWSDNQEI VLKGGDVVRL
     FHAEQEKFLT CDDHRKKQYV FLRTTGRQSA TSATSSKALW EVEVVQHDPC RGGAGYWNSL
     FRFKHLATGH YLAAEVNPEY EEEGPESRSP LELEQEALRA RLRNVQDKVM YTLVSVPDGN
     DISSIFELDP TTLRGGDSLV PRNSYVRLRH LCTNTWVHST NQPIDKEEEK PVMLRIGTST
     LKEDKEAFAI VPVSPAEVRD LDFANDASKV LASIAGKLEK GTITQNERRA VTKLLEDLVF
     FVVDIPNSGQ DVLEIMVNKP NRERQKLMRE QNILKQIFKL LQAPFTDSGD GPMLRLEELA
     DQRHAPFRHI CRLCYRVLRH SQQDYRKNQE YIAKQFRFMQ KQIGYDVLAE DTITALLHNN
     RKLLEKHITA AEIDTFVSLV RKNREPRFLD YLSDLCVSMN KSIPVTQELI CNAVLDQANA
     DILIETKLVL SRFEIEGAPL GENSLESEED EEEVWLFWKD NNNKEIRSKS IRELAQDAKE
     GQKEDQEVIG YYRYQLNLFA RMCLDRQYLA INKISGQLDV DLILRCMSDE DLPFDLRASF
     CRMMLHMHVD RDPQEQVTPV KYARLWSEIP SEIAIDDYDN DGTSKDEIKE RFCQTMEFVE
     NYLRDVVCQS FPFADKEKNK LTFEVVNLAR NLIYFGFYNF SDLLRLTKIL LAILDCVHVG
     TIFGLNKLDK EDESKGSNVM KSIHGVGELM SHVVLRGGGF LPMTSSSSTS RDTVKTQTEP
     EKQDILVMDT KLKIIEILQF ILNVRLDYRI SCLLSIFKRE FDESNSQSEL TVGGAVEGPN
     NMPGALDFEH IEEQAEGIFG GSEENTPLDL DDHGGRTFLR VLLHLTMHDY PPLVSRALQL
     LFRHFSQRQE VLQAFKQVQL LVTSQDVENY KQIKSDLDQL RSIVEKSELW VYKRQGSEEG
     MDAGEPEHKL GDAVGTDKTK KPESTSSYNY RVVKEILLRL SKLCVQEGLS GRKSKKQQQR
     LLRNMGAHAV VLELLQIPYE KGEDLRMQDI MKLAHQFLQN FCAGNQQNQA LLHKHINLFL
     NPGILEAITM QHIFMNNFQL CSEINERVVQ HFVHCIETHG RNVQYLKFLQ TIVKAENKFI
     KKCQDIVMAE LVNAGEDVLV FYNDRASFQT LVQMMRSERD RMDENSPLMY HIHLVELLAV
     CTEGKNVYTE IKCNSLLPLD DIVRVVTHED CIPEVKIAYI NFLNHCYVDT EVEMKEIYTS
     NHMWKLFENF LVDICRVCNS TSERKHADTI LERYVTETVM SIVTTFFSSP FSDQSTSLQT
     RQPVFVQLLQ AIFRVYHCNW LIPVQKGSVE SCIKVLSDVA KGRAIAIPVD LDNQVHNLFV
     KSNNIVQKTA MSWRLSARNA ARRDSMVTAS RDYRNIIERL QDIVSALEDR LRPLVQAELS
     VLVDVLHRPE LLFPENTDSR KKCESGGFIC KLIKHTKQLL EENEERLCIK VLQTLREMMT
     KDRGYGEKGE ALRQILVNRY YGNFHRSGGR RDSLTFANGP LSPIGPGKSQ SGLGGPGALS
     RGEMSLAEVQ CHLDKEGASD LVIDLIMNTT SDRVFQESIL LAIALLEGGN TTIQRSFFCR
     LTEDKKSEKF FRVFYDRMKL AQLEIKATVT VNTSDLGNRK REDDNQDKDG PVRKKARESS
     VVMTEDVREQ LLEASSATKK AFNSYRREAD PEDHFNVVDG QSSAGDKNQD EGEMSFVIVI
     MQPILRFLQL LCENHNRDLQ NFLRCQNNKN NYNLVCETLQ FLDCICGSTT GGLGLLGLYI
     NEKNVALINQ TLESLTEYCQ GPCHENQNCI ATHESNGIDI IIALILNDIN PLGKKRMDLV
     LELKNNASKL LLAIMESRHD SENAERILYN MRPKELVEVI KKAYLQGEVE IEDTKEEEEN
     EEEDHDAASP RNVGHNIYIL AHQLARHNKE LAVMLKPGVA VGEGDEALEC YAKHTAQIEI
     VRQDRTMEEI VFPVPNICEF LTTESKLRVY YTTERDEQGS KINDFFLRAE DLFNEMNWQK
     KLRAQPVLYW CSRNMSVWSN ICFNLALLMN LLVCLFYPLE GVQGVMLDPH LSALLWMGVV
     AALVIVLVMP QPLSVRALVI ITILRLIFSV GLEPTLFLLG ALNVCNKIIF MISFVGNRGT
     FTRGYKAMVL DFEFLYHLIY LIICCLGVFV HVFFYSLLLF DLVYREETLL NVIKSVTRNG
     RSIVLTAVLA LILVYLFSIV GYIFFKDDFI LEVDRVPNAT TKGGGSLASV FVPAGMCQGG
     TDQNCTARAQ REGDRDRVGG DGDGDKDEDV ERTCDSLLMC IVTVLSHGLR SGGGVGDVLR
     KPSKEEPLFA ARVIYDLLFF FMVIIIVLNL IFGVIIDTFA DLRSEKQKKE EVLKTTCFIC
     GLERDKFDNK TVTFEEHIKE EHNMWHYLFF IVLVKVKDST EYTGPESYVA EMIKEHNLDW
     FPRMRAMSLV SSDAEGEQNE IRNLQEKLES TMRLVANLSG QLSELKDQMT EQRKHKQRIG
     LLGHPPHMNI NPQQPA
//
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