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Database: UniProt
Entry: H2TJZ6_TAKRU
LinkDB: H2TJZ6_TAKRU
Original site: H2TJZ6_TAKRU 
ID   H2TJZ6_TAKRU            Unreviewed;      2626 AA.
AC   H2TJZ6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000025000};
GN   Name=LOC101074739 {ECO:0000313|Ensembl:ENSTRUP00000025000};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000025000, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000025000}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000025000}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSTRUT00000025103; ENSTRUP00000025000; ENSTRUG00000009941.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   Proteomes; UP000005226; Chromosome 19.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2168   2190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2202   2222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2250   2268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2288   2315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2336   2358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2447   2470       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    164       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      171    221       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      229    285       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      292    361       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      367    423       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1561   1581       {ECO:0000256|SAM:Coils}.
FT   COILED     2557   2605       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2626 AA;  300518 MW;  04CF84B9B8FE093F CRC64;
     MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PDAGDLNNPP KKFRDCLFRL
     CPMNRYSAQK QFWKAAKPGG NTDAVLLNKL HHAADLEKKQ NDSENKKLLG TVIQYGNVIQ
     LLHLKSNKYL TVNKRLPALL EKNAMRVMLD TAGNEGSWFY IQPFYKLRSI GDSVVIGDKV
     VLNPVNAGQP LHASTHQLVD NPGCNEVNSV NCNTSWKIVL FMKWSDNQEI VLKGGDVVRL
     FHAEQEKFLT CDDHRKKQYV FLRTTGRQSA TSATSSKALW EVEVVQHDPC RGGAGYWNSL
     FRFKHLATGH YLAAEVNPEY EEEGPESRSP VSGNVQDKVM YTLVSVPDGN DISSIFELDP
     TTLRGGDSLV PRNSYVRLRH LCTNTWVHST NQPIDKEEEK PVMLRIGTST LKEDKEAFAI
     VPVSPAEVRD LDFANDASKV LASIAGKLEK GTITQNERRA VTKLLEDLVF FVVDIPNSGQ
     DVLEIMVNKP NRERQKLMRE QNILKQIFKL LQAPFTDSGD GPMLRLEELA DQRHAPFRHI
     CRLCYRVLRH SQQDYRKNQE YIAKQFRFMQ KQIGYDVLAE DTITALLHNN RKLLEKHITA
     AEIDTFVSLV RKNREPRFLD YLSDLCVSMN KSIPVTQELI CNAVLDQANA DILIETKLVL
     SRFEIEGAPL GENSLESEED EEEVWLFWKD NNNKEIRSKS IRELAQDAKE GQKEDQEVIG
     YYRYQLNLFA RMCLDRQYLA INKISGQLDV DLILRCMSDE DLPFDLRASF CRMMLHMHVD
     RDPQEQVTPV KYARLWSEIP SEIAIDDYDN DGTSKDEIKE RFCQTMEFVE NYLRDVVCQS
     FPFADKEKNK LTFEVVNLAR NLIYFGFYNF SDLLRLTKIL LAILDCVHVG TIFGLNKLDK
     EDESSNVMKS IHGVGELMSH VVLRGGGFLP MTSSSSTSRD TVKTQTEPEK QDILVMDTKL
     KIIEILQFIL NVRLDYRISC LLSIFKREFD ESNSQSELTV GALDFEHIEE QAEGIFGGSE
     ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSRALQLLFR HFSQRQEVLQ AFKQVQLLVT
     SQDVENYKQI KSDLDQLRSI VEKSELWVYK RQGSEEGMDA GEPEHKLVQY LKPESTSSYN
     YRVVKEILLR LSKLCVQEGL SGRKSKKQQQ RLLRNMGAHA VVLELLQIPY EKGEDLRMQD
     IMKLAHQFLQ NFCAGNQQNQ ALLHKHINLF LNPGILEAIT MQHIFMNNFQ LCSEINERVV
     QHFVHCIETH GRNVQYLKFL QTIVKAENKF IKKCQDIVMA ELVNAGEDVL VFYNDRASFQ
     TLVQMMRSER DRMDENSPLM YHIHLVELLA VCTEGKNVYT EIKCNSLLPL DDIVRVVTHE
     DCIPEVKIAY INFLNHCYVD TEVEMKEIYT SNHMWKLFEN FLVDICRVCN STSERKHADT
     ILERYVTETV MSIVTTFFSS PFSDQSTSLQ TRQPVFVQLL QAIFRVYHCN WLIPVQKGSV
     ESCIKVLSDV AKGRAIAIPV DLDNQVHNLF VKSNNIVQKT AMSWRLSARN AARRDSMVTA
     SRDYRNIIER LQDIVSALED RLRPLVQAEL SVLVDVLHRP ELLFPENTDS RKKCESGGFI
     CKLIKHTKQL LEENEERLCI KVLQTLREMM TKDRGYGEKG EALRQILVNR YYGNFHRSGG
     RLGGPGALSR GEMSLAEVQC HLDKEGASDL VIDLIMNTTS DRVFQESILL AIALLEGGNT
     TIQRSFFCRL TEDKKSEKFF RVFYDRMKLA QLEIKATVTV NTSDLGNRKR EDDNQDKDGP
     VRKKARESSV VMTEDVREQL LEASSATKKA FNSYRREADP EDHFNVVDGQ SSAGDKNQDE
     GEMSFVIVIM QPILRFLQLL CENHNRDLQN FLRCQNNKNN YNLVCETLQF LDCICGSTTG
     GLGLLGLYIN EKNVALINQT LESLTEYCQG PCHENQNCIA THESNGIDII IALILNDINP
     LGKKRMDLVL ELKNNASKLL LAIMESRHDS ENAERILYNM RPKELVKIEE NEEEDHDAAS
     PRNVGHNIYI LAHQLARHNK ELAVMLKPGV AVGEGDEALE CYAKHTAQIE IVRQDRTMEE
     IVFPVPNICE FLTTESKLRV YYTTERDEQG SKINDFFLRA EDLFNEMNWQ KKLRAQPVLY
     WCSRNMSVWS NICFNLALLM NLLVCLFYPL EGGDLGQFML DPHLSALLWM GVVAALVIVL
     VMPQPLSVRA LVIITILRLI FSVGLEPTLF LLGALNVCNK IIFMISFVGN RGTFTRGYKA
     MVLDFEFLYH LIYLIICCLG VFVHVFFYSL LLFDLVYREE TLLNVIKSVT RNGRSIVLTA
     VLALILVYLF SIVGYIFFKD DFILEVDRVP NATTSESGFL SLFQPNVKGG DGDGDKDEDV
     ERTCDSLLMC IVTVLSHGLR SGGGVGDVLR KPSKEEPLFA ARVIYDLLFF FMVIIIVLNL
     IFGVIIDTFA DLRSEKQKKE EVLKTTCFIC GLERDKFDNK TVTFEEHIKE EHNMWHYLFF
     IVLVKVKDST EYTGPESYVA EMIKEHNLDW FPRMRAMSLV SSDAEGEQNE IRNLQEKLES
     TMRLVANLSG QLSELKDQMT EQRKHKQRIG LLGHPPHMNI NPQQPA
//
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