ID H2TK82_TAKRU Unreviewed; 193 AA.
AC H2TK82;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=NBL1, DAN family BMP antagonist {ECO:0000313|Ensembl:ENSTRUP00000025086.3};
GN Name=nbl1 {ECO:0000313|Ensembl:ENSTRUP00000025086.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000025086.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000025086.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000025086.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003973311.2; XM_003973262.2.
DR AlphaFoldDB; H2TK82; -.
DR Ensembl; ENSTRUT00000025189.3; ENSTRUP00000025086.3; ENSTRUG00000009969.3.
DR GeneID; 101064794; -.
DR KEGG; tru:101064794; -.
DR CTD; 4681; -.
DR eggNOG; ENOG502RYP0; Eukaryota.
DR GeneTree; ENSGT00940000154209; -.
DR InParanoid; H2TK82; -.
DR OMA; ECPGHEV; -.
DR OrthoDB; 3684148at2759; -.
DR TreeFam; TF106445; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF5; NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1; 1.
DR Pfam; PF03045; DAN; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..193
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025611514"
FT DOMAIN 42..128
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 172..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 42..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 193 AA; 21066 MW; 0D7DAB0DCC1BB7AA CRC64;
MGKGAVMWQR IQICCTLFAL CSAAPPAHIN RLALFPDKSA WCEAKNITQI VGHTGCLPQS
IQNRACLGQC FSYSVPNTFP QSTESLVHCD SCMPAQTQWE VVTLDCPDSP NVDKLVERIF
HCSCQSCSKE GVQERALMQL YPADVAKDAP SLSDPPSVLE SQTHLLLSAD ADPHKHAHPH
TDHHILPHTS DGG
//
