ID H2TK98_TAKRU Unreviewed; 1276 AA.
AC H2TK98;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Euchromatic histone lysine methyltransferase 1 {ECO:0000313|Ensembl:ENSTRUP00000025102.2};
GN Name=ehmt1 {ECO:0000313|Ensembl:ENSTRUP00000025102.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000025102.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000025102.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000025102.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011602759.1; XM_011604457.1.
DR AlphaFoldDB; H2TK98; -.
DR Ensembl; ENSTRUT00000025205.3; ENSTRUP00000025102.2; ENSTRUG00000009977.3.
DR GeneID; 101072913; -.
DR CTD; 402830; -.
DR GeneTree; ENSGT00940000156002; -.
DR HOGENOM; CLU_005790_3_0_1; -.
DR OrthoDB; 5481936at2759; -.
DR Proteomes; UP000005226; Chromosome 6.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT REPEAT 747..779
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 780..812
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 813..846
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 847..879
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 913..945
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1035..1098
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1101..1218
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..295
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..354
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..387
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..419
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 138963 MW; 7FE3575D34A2E3C6 CRC64;
MASVAPEPAG LAKGSVDMGA STHNLDPEQE KPGDKEARHV SSPPAEALLN GTECDDIGHE
IPNDSSETNK TLLLVNENGA VDTEPPHGSV TGSNGLILTK LPQEGDSTAT TVMGVTPHRT
NWSPSGSAAG GHMANHISGC AQSSGARQTD HGTGNSSGQG APDTNNCTSL SPATTRATIT
VHRARKTMSR PAVSPAQKLL NKELREAKSA KMKTNVTPDT QTSSLQSSHQ NHLPQSLPDT
AASAQKASSA LPGAPSADAS PPASAKPHLG SISGGLSMRK KKRRMGTYSL VPKKKTKVLR
QKSVLEIFKE LQQTATSPQS EAVVNINGEK IENASDEEES EEVDSEETEE PVSAVEETSE
PISQEGEEQE SEQSGDGEAE EEGTESDLSS ESSLKKKLKK KTKADSAWLR PRKRKKRIKA
KDSEAMDQSQ PPVGAQIDES GEYTHISSAE PVNLSKSKEL SEPSQIKESL DSSIEEAQEL
PLCSCRMETP KSREILTLAD RKCMATESID GQLIRCQGAI LKHEMMRPSN SVQLLVLCED
HRNGMVKHQC CPGCGFFCRA GTFMECQPDI SISHRFHRAC ASVLKGQSFC PHCGEEASKA
KEVTIAKADT TSTVPPVVVH GGATAAVPEG RADTTTDILS QLAVDTEVGS KAEHFLPDRL
HISPLPGSSS FTLVPPRSGT TEQAPVPAGP PRETLESILV ALDTEKPKKL RFHPKQLYHS
AKQGELKKVF LMLVDGIDPN FKMESQNKRT PLHAAAEGGH SDICHMLVQA GANLDICDDD
HRTPLMEACE NNHMATVLYL LRAGANATQK DVEGFTCLHL AAKSGHYAIV EHLLLTGLIN
INCQDDGGWT PMIWATEYKH VDQVKLLLSK GADISIRDKE ENICLHWAAF SGCVDIAVLL
LDANCDMHAV NIHGDSPLHI AARENRLECV TLFLSQGANV FLRNREGETP PDCCGHNSKA
WAVLQASRKE RGSNSSMDKA EEKVLHSDIA LGHERVPIPC VNSVDSEPYP EGYKYIPENC
VTSPMNIDRN ITHMQYCVCK ENCSTSICMC GQLSLRCWYD KTGRLLPEFC REEPPLIFEC
NHACSCWRTC KNRVVQNGLR TKLQLFRTSK KGWGVRAHQD IPQGTFVCEY VGEIISEAEA
EMRQNDAYLF SLDDKPQDLY CIDARFYGNI SRFLNHMCEP NLFACRVFTT HQDLRFPHIA
FFASENIKAG EELGFDYGSH FWEVKSKVFN CECGSSKCRY SSAAMATLQA DSTPEDQQQP
SASPDTSSSN SPSSPP
//
