ID H2TMY0_TAKRU Unreviewed; 1321 AA.
AC H2TMY0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Collagen type II alpha 1 chain {ECO:0008006|Google:ProtNLM};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026036.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000026036.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000026036.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 31033.ENSTRUP00000078264; -.
DR Ensembl; ENSTRUT00000026141.3; ENSTRUP00000026036.3; ENSTRUG00000010345.3.
DR GeneTree; ENSGT00940000155639; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR000885; Fib_collagen_C.
DR InterPro; IPR001007; VWF_dom.
DR NCBIfam; NF040941; GGGWT_bact; 1.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF58; COLLAGEN ALPHA-1(II) CHAIN; 1.
DR Pfam; PF01410; COLFI; 1.
DR Pfam; PF01391; Collagen; 10.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00038; COLFI; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR PROSITE; PS51461; NC1_FIB; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1321
FT /note="Collagen type II alpha 1 chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025499803"
FT DOMAIN 35..93
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1087..1321
FT /note="Fibrillar collagen NC1"
FT /evidence="ECO:0000259|PROSITE:PS51461"
FT REGION 129..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..957
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1049
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 129772 MW; 1859A9803BC185FA CRC64;
MFSFMDSRIV LLLVASQVCL LTVVRCQEED DQATLSCMQD GQRYSDKDVW KPEPCRICVC
DTGTVLCDEI VCEELKDCRN PEIPFGECCP ICAADQSPPI GRNLFISHFI INKLLHILML
FVLEEGMKGS AGPRGRDGEP GTPGNPGSPG PPGPPGLGGN FAAQMAGGFD EKAGGGAQMG
VMQGPMVSKR SGPMGPRGPP GPSGKAGEDG ARGFPGTPGL PGIKGHRGYS GIDGAKGETG
AVGSKGESGA PGENGAPGPM GPRGLPGERG RPGPSGVAGA RGNDGLPGPA GPPGPVGPSG
APGFPGSPGS KGEAGPTGAR GPEGAQGPRG ESGTPGSPGP SGASGNPGTD GIPGAKGSAG
AHGIAGAPGF PGPRGPPGPQ GATGPLGPKG TSGDPGIAGF KGEAGPKGEI GPAGLQGAPG
QQGEEGKRGP RGEPGAAGPI GPPGERGAPG NRGFPGQDGL AGSKGAPGER GTSGASGPKG
ANGDPGRPGE SGLPGARVRA DHCHNCYMCG APGEDGRPGP PGPQGARGQP GVMGFPGPKG
ASVSTDTFGQ IQKSLLRLGG VPGEAGASGT TGPRGERGFP GERGAAGPQG LQGPRGLPGT
PGTDGPKGAI GPHGSLGAQG PPGLQGMPGE RGGAGIPGPK GDRGDLGEKG PEGAPGKDGA
RGLTGPIGPP GPSGPNGEKV SDIYLLQALL LQGSDGQPGI KGEQGETGQK GDAGAPGPQG
PSGAPGPAGP TGVSGPKGAR GAQGPPGATG FPGAAGRVGP PGPNGNPGPA GPAGSPGKDG
PKGIRGDGGP PGRQGDAGLR GPAGPSGEKG DAGEDGPVGP PGPSGPQGLG GQRGIVGLPG
QRGERGFPGL PGPSGEPGKQ GAPGTGGDRG PPGPVGPPGL TGPAGESGRE GNPGSDGPPG
RDGATGIKGD RGDTGPTGSP GAPGAPGAQG PVGQTGKQGD RGESVSSNSN KHGNTRFICF
TGPQGPRGDK GEGGESGERG QKGHRGFTGL QGLPGPPGPP GPVGPSGKDG AFGLPGPIGP
PGPRGRSGET GPAGPPGNSG PPGLPGPPGP GIDMSAFAGL GQTEKGPDPL RYMRADQASG
NLRQHDAEVD ATLKSLNNQI ENIRSPEGSK KNPARTCRDL KLCHPDWKSG EYWIDPNQGC
TVDAIKVYCD METGETCVQP KPSSISRKNW WTSKSKDRKH VWFSETMNGG FHFSYGDDSL
APNTAAIQMT FLRLLSTEAS QNLTYHCKNS VAYMDASTGN LKKAVLLQGS NDVEIRAEGN
SRFTYSVLED GCTKHTGQWG KTLIEYRSQK TSRLPIVDIA PMDIGEAHQE FGVEVGAVCF
L
//
