ID H2TN43_TAKRU Unreviewed; 357 AA.
AC H2TN43;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=PAK1 interacting protein 1 {ECO:0000313|Ensembl:ENSTRUP00000026099.3};
GN Name=pak1ip1 {ECO:0000313|Ensembl:ENSTRUP00000026099.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026099.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000026099.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000026099.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2TN43; -.
DR STRING; 31033.ENSTRUP00000026099; -.
DR Ensembl; ENSTRUT00000026204.3; ENSTRUP00000026099.3; ENSTRUG00000010365.3.
DR eggNOG; KOG0294; Eukaryota.
DR GeneTree; ENSGT00390000001263; -.
DR HOGENOM; CLU_031466_2_0_1; -.
DR InParanoid; H2TN43; -.
DR OMA; FGYRVKT; -.
DR OrthoDB; 198243at2759; -.
DR TreeFam; TF326684; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44675:SF1; P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR44675; PAK1 INTERACTING PROTEIN 1; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 36..68
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 76..116
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 117..158
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 357 AA; 39730 MW; 7627A6E83FBF52C0 CRC64;
MASVLELVAG SYEQITFGYR VKTDDKEWTP KADFTHHAHT AAITTVAASE RFVVTGSNDE
TIQLYDMKKR VEHGALLHHN GTITCLEFYG SSHLLSGGQD GLVCVWNTKK WQCLKSIRAH
KGSVMSLSVH PSGKLALTVG TDQTLRTWNL INGRSAFIKN IKQNSHIVRW SPDGDKYAVV
IDDRVDIYEL ETASVTATIT NPKRISSLQF LNNSILAIAG DDESVRLHDM SEKKMVCEFK
AHETRVKAMD SFVMEDYCVM VTASNDGLIK MWKLHLKEEL ETPTLLGEVN TSARLTCLAV
WKPSSVPSAF TEESAEKAAT SEGLVTELSK TRRVRIAEEV ILEDESKPKK KKKDGGK
//
