ID H2TP55_TAKRU Unreviewed; 608 AA.
AC H2TP55;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Nucleoside diphosphate kinase B {ECO:0000256|ARBA:ARBA00013499};
GN Name=LOC101061845 {ECO:0000313|Ensembl:ENSTRUP00000026461.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026461.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000026461.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000026461.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Major role in the synthesis of nucleoside triphosphates other
CC than ATP. {ECO:0000256|ARBA:ARBA00003465}.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|ARBA:ARBA00008142,
CC ECO:0000256|RuleBase:RU004011}.
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DR AlphaFoldDB; H2TP55; -.
DR STRING; 31033.ENSTRUP00000087389; -.
DR Ensembl; ENSTRUT00000026568.3; ENSTRUP00000026461.3; ENSTRUG00000010490.3.
DR GeneTree; ENSGT00940000164537; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR CDD; cd04416; NDPk_TX; 3.
DR CDD; cd02948; TRX_NDPK; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 3.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46135; NME/NM23 FAMILY MEMBER 8; 1.
DR PANTHER; PTHR46135:SF3; THIOREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00334; NDK; 3.
DR Pfam; PF00085; Thioredoxin; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00562; NDK; 3.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 3.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 154..298
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
FT DOMAIN 309..443
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
FT DOMAIN 444..581
FT /note="Nucleoside diphosphate kinase-like"
FT /evidence="ECO:0000259|SMART:SM00562"
FT REGION 583..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 68455 MW; 55F1AB15540AFEDE CRC64;
MYCMYNILFF VQVSVTNQEQ WEEMLAVKGL TVVDVYQQWC GPCRVVVSLL KKIYNELGDD
LLHFATAEAD NIDALARYRG KCEPTFLFYG GGELVGVLRG ANAPLLQRMI VQKLGEEKMV
LEKGVERKVV SHEINMYSVT HVRPAFPPVV PANKSYTVAI IKPDAVAHGK VNEIIMKIQN
AGFQILAHEE RRLTEDEARD FYRHKTAEPC FEDLVRFMSS GPSHILILSQ AEGSANVVPA
WREFIGPADT EEAKRERPES LRAQYGTEAL SNAVHGSENI EQASRELAFF FPNFRMASQT
EQDGKEEHAE RTLALIRPDV ARERREEILS QIKKAGFTVA LQREVLLTEE QVRQFYSQHV
KEDYFPALLH TMASGPVLAL ALARQAAVCH WRNLLGPSDV NKAKEESPEC LRAQFAVENH
PINQLHGSAS QEEADREISF FFPQQQTLAV IKPDALREHK ETILEEIRGS GFSVVQSKEM
VLTKEMAEEL YMEHKEKPYF SQVVEFMSSG PCMMLILNKE NAVEEWRAMM GPADPEQAKA
TCPNSMRARF ASNILHNSLH GASTEERAKE KIHFIFGDIC SDVEPGGEGE TDRTDIGAAA
GQNLKPDT
//
