ID   H2TP67_TAKRU            Unreviewed;      1033 AA.
AC   H2TP67;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Transmembrane protein 132E {ECO:0000313|Ensembl:ENSTRUP00000026473.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026473.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000026473.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000026473.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the TMEM132 family.
CC       {ECO:0000256|ARBA:ARBA00006166}.
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DR   AlphaFoldDB; H2TP67; -.
DR   STRING; 31033.ENSTRUP00000026473; -.
DR   Ensembl; ENSTRUT00000026580.3; ENSTRUP00000026473.3; ENSTRUG00000010494.3.
DR   GeneTree; ENSGT00940000158479; -.
DR   HOGENOM; CLU_009871_0_0_1; -.
DR   InParanoid; H2TP67; -.
DR   OMA; GEMVPRR; -.
DR   Proteomes; UP000005226; Chromosome 15.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0060117; P:auditory receptor cell development; IEA:Ensembl.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR   GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR   InterPro; IPR026307; TMEM132.
DR   InterPro; IPR031436; TMEM132_C.
DR   InterPro; IPR031437; TMEM132_M.
DR   InterPro; IPR031435; TMEM132_N.
DR   PANTHER; PTHR13388:SF7; TRANSMEMBRANE PROTEIN 132E; 1.
DR   PANTHER; PTHR13388; UNCHARACTERIZED; 1.
DR   Pfam; PF16070; TMEM132; 1.
DR   Pfam; PF15706; TMEM132D_C; 1.
DR   Pfam; PF15705; TMEM132D_N; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        854..879
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          20..159
FT                   /note="Transmembrane protein TMEM132 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15705"
FT   DOMAIN          406..751
FT                   /note="Transmembrane protein family 132 middle"
FT                   /evidence="ECO:0000259|Pfam:PF16070"
FT   DOMAIN          827..907
FT                   /note="Transmembrane protein TMEM132 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF15706"
FT   REGION          915..982
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        936..970
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1033 AA;  114786 MW;  45AF64B872D8C031 CRC64;
     LSSLPMTASP PPPSVYLPAS FKMSNAQLAF FLREAQITGQ TFGGGGKSGS GPGTGHPLQR
     SESFVVFQTK DVPAVNISFG PFARDQALSK DLLQPTSPLD IPGQLTVNWK VRAFIVQARV
     FSNNPTVQVF FYIAGRDWDD FKAQDKLPCV RLHAFRDVRE IKTSCRMKGN LAQCLAQLEL
     PPSWFNTNVA PLGRRKGSSD SLLDGLSSET LQAELYYTLH WPNTDGEGEP PSQHPLLRIG
     SISLYQASQE QLLVDKQLDK NMFLRLPEKP LKPGETLKIS LFLMPNSTIE QFTLKVKAKK
     GVNLLQTRSK NAQWRVDWEV QSGAKHSITT IDVNKNKVKE VMGNVEVMQL DFEMENFTSL
     SVTRRINWNI DYRGQNPALD SEKVVTELTV VQRDIQAIIP LAMDTEIINT AILTGRTVAI
     PVKMVSIEMN GAVTDVSTFV QCKSANEDIV KVSMNCDYVF VNGKESRGSM NARVIFSYEH
     LSAPLELTVW VPKLPLQVEL SDSNLSFIKG WRVPILPDRR TRDSDADDED EERRVSRGCT
     LQYQRALVKV LTQFHTTSTE GTDQVITMLG PDWQVDVTDL VQDFLKVADP RIAELVDRTI
     LVGLELGSTV LKVESPLAMD AVLGESAFSV TDDKVSITEM RVSAISGLTL TLHPSPGNSH
     TIVAKATGVQ TLTAPKQEAS LSIWMLFSDN TAATLTYFDP KDYNLNASTL DDKVASVSQE
     PQQRWPVVVA EGEGAGELVR VEMTICETCQ KTKRKSVIAS AAVYIKVRFG PEEDSEEEVT
     TESETELAPI TRRPMFDPNI SGRIYETSNE QPASVPIDYT NFPTISNQEL PTESDEEEEE
     DLVHSRRNMT DLEIGMYALL GVFCLAILVF LINCIVFVLK YRHKRIPPEG QANMDHSHHW
     VFLGNGQPLR AQCELSPHQV ESPGNPLEGV QTCCHGDHHS SGSSQTSVQS QVHGRGDGSS
     GGSTKENGED ASSPTSKRKR VKFTTFTTLP TEELPYNSIP IADEEDIQWV CQDMGFQDPE
     ELHDYMRRIK EIA
//