ID H2TRN3_TAKRU Unreviewed; 308 AA.
AC H2TRN3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=T-cell surface glycoprotein CD4-like {ECO:0000313|Ensembl:ENSTRUP00000027340.3};
GN Name=LOC101075815 {ECO:0000313|Ensembl:ENSTRUP00000027340.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027340.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000027340.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000027340.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; H2TRN3; -.
DR STRING; 31033.ENSTRUP00000027340; -.
DR Ensembl; ENSTRUT00000027449.3; ENSTRUP00000027340.3; ENSTRUG00000010825.3.
DR GeneTree; ENSGT00510000054197; -.
DR HOGENOM; CLU_882686_0_0_1; -.
DR InParanoid; H2TRN3; -.
DR OMA; KPKKYCQ; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.5.900; transmembrane domain of human cd4; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11422:SF6; CD4-2 MOLECULE, TANDEM DUPLICATE 2-RELATED; 1.
DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..308
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025503373"
FT TRANSMEM 227..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 108..190
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 286..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 308 AA; 33788 MW; 42419405D82C8E47 CRC64;
MKRTLWLGFA VFFSCALCAD GYVVVKSPGE KVNLPCGADQ SGGTVIWKHE GSVVIQVDKN
GFPRKGQGDL GRRATVRRMA LEITGVKEAD AGMFTCTVDR NSEQHFLFVV TVSATPSAVL
QLGSSAALHC QVKGLPPPSA PQWRKPDGSP HPGSEVAELN PVARSDEGAW NCTFSHGGLT
YGKSLDIRVT GAATTPAKPV PSDKGKEAPT CNDCVTNRPS LPLRLSWWMW AVIAVGCLIL
VVLMAFIVYL CKRIQRKKRK LRRMENSRQL LMPKQYCQCN RPTAVPKMQQ RRQRQKPSAP
PLQPVLVQ
//