ID H2TS08_TAKRU Unreviewed; 621 AA.
AC H2TS08; H2TS04;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=slc6a2 {ECO:0000313|Ensembl:ENSTRUP00000027466.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027466.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000027466.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000027466.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR RefSeq; XP_003969582.1; XM_003969533.2.
DR RefSeq; XP_011607997.1; XM_011609695.1.
DR RefSeq; XP_011607998.1; XM_011609696.1.
DR AlphaFoldDB; H2TS08; -.
DR STRING; 31033.ENSTRUP00000027466; -.
DR Ensembl; ENSTRUT00000027575.3; ENSTRUP00000027466.2; ENSTRUG00000010868.3.
DR GeneID; 101067849; -.
DR KEGG; tru:101067849; -.
DR CTD; 6530; -.
DR GeneTree; ENSGT00940000158960; -.
DR InParanoid; H2TS08; -.
DR OMA; NLWGFAY; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF307; SODIUM-DEPENDENT NORADRENALINE TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 69..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 621 AA; 69700 MW; EE8AB7DAEF154779 CRC64;
MNIMPEHKLS SVAPLNQCNA EKKEVELILV KDQNGVQYTS SSIIPSPSDR VGHIGTEDNR
ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLI PYILFLVIAG MPLFYMELAL
GQYNREGAAT VWKICPVFKG VGYTVILIAL YVGFYYNVII AWSLYYLFSS MTNELPWLGC
DNSWNSENCT DPQVINGSVI GNGTSYAKYK ITPAAEFYER GVLHLHESRG IHDLGLPRWD
LSLCLVVVVF ILFFSLWKGV KSSGKVVYIT ATMPYVVLFV LLIRGVTLPG SMEGIKAYLH
IDFKRLNNLE VWIDAATQIF YSLGAGFGVL IAFASYNKFD NNCYRDALLT TSVNCVTSFF
SGFVIFSVLG YMADKHKVSI EDVATEGAGL VFIIYPEAIS TLPGSTFWAI LFFIMLLTLG
IDSAMGGMEA VITGLTDEFK ILKRHRKLFT FATAFLTFLF ALLCVTNGGI YVLTLLDKYA
AGTSILFGVL IEAIGVSWFY GVDRFSEDIE RMMGFKPGLY WRLCWKFVSP LFLLFVVIAS
TLTSSGLKYD EYVFPDWANV VGWGVAMSSM LFVPFYAIYK FFSLSGSFKE RIGYCITPEH
EHHLVAEGNV RQFKLRHWLA I
//