ID H2TSC0_TAKRU Unreviewed; 268 AA.
AC H2TSC0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=COP9 signalosome subunit 7A {ECO:0000313|Ensembl:ENSTRUP00000027578.2};
GN Name=cops7a {ECO:0000313|Ensembl:ENSTRUP00000027578.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027578.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000027578.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000027578.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the COP9 signalosome complex (CSN), a complex
CC involved in various cellular and developmental processes. The CSN
CC complex is an essential regulator of the ubiquitin (Ubl) conjugation
CC pathway by mediating the deneddylation of the cullin subunits of SCF-
CC type E3 ligase complexes, leading to decrease the Ubl ligase activity
CC of SCF-type complexes such as SCF, CSA or DDB2. The complex is also
CC involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA,
CC ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
CC kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and
CC protects degradation by the Ubl system, respectively.
CC {ECO:0000256|ARBA:ARBA00025037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
CC {ECO:0000256|ARBA:ARBA00008482}.
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DR RefSeq; XP_003966345.1; XM_003966296.2.
DR AlphaFoldDB; H2TSC0; -.
DR STRING; 31033.ENSTRUP00000027578; -.
DR Ensembl; ENSTRUT00000027687.3; ENSTRUP00000027578.2; ENSTRUG00000010919.3.
DR GeneID; 101069282; -.
DR KEGG; tru:101069282; -.
DR CTD; 50813; -.
DR GeneTree; ENSGT00940000159873; -.
DR InParanoid; H2TSC0; -.
DR OMA; DIDSRGH; -.
DR OrthoDB; 931897at2759; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0008180; C:COP9 signalosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0010387; P:COP9 signalosome assembly; IEA:InterPro.
DR InterPro; IPR045237; COPS7/eIF3m.
DR InterPro; IPR041481; CSN7_helixI.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR15350; COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17; 1.
DR PANTHER; PTHR15350:SF10; COP9 SIGNALOSOME COMPLEX SUBUNIT 7A; 1.
DR Pfam; PF18392; CSN7a_helixI; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 1..146
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 207..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 29258 MW; 7D06519478BF23D4 CRC64;
MESEQLLSLS GSALAQAVGS LLETPGLYVF SDILELPNVK ELENGPHAPV YQLLNLFAYG
TYCDYKERAA SLPELTPAQR NKLRHLSIIS LASNLKCLPY SLLLQQLELK NVRELEDLLI
EAVYCDIIQG KLDQRNQQVE VDCSVGRDLG PNELPNIVNT LQEWCTGCEA VLCGIEEQVS
RANQYRESQL KVKIQVETEV SNLQKTLKAS AASPSSGPAP AGAASNQDAD QPAEPRDPAS
SQEPRQPGKK SSKVKGLRGS GKIWSKSN
//
