ID H2TUB5_TAKRU Unreviewed; 249 AA.
AC H2TUB5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Tubulin folding cofactor B {ECO:0000313|Ensembl:ENSTRUP00000028274.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028274.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000028274.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000028274.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TBCB family.
CC {ECO:0000256|ARBA:ARBA00025779}.
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DR AlphaFoldDB; H2TUB5; -.
DR STRING; 31033.ENSTRUP00000028274; -.
DR Ensembl; ENSTRUT00000028386.3; ENSTRUP00000028274.2; ENSTRUG00000011197.3.
DR eggNOG; KOG3206; Eukaryota.
DR GeneTree; ENSGT00940000156119; -.
DR HOGENOM; CLU_067577_2_0_1; -.
DR InParanoid; H2TUB5; -.
DR OMA; DQYEQRT; -.
DR TreeFam; TF313444; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0043014; F:alpha-tubulin binding; IEA:InterPro.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0007021; P:tubulin complex assembly; IEA:InterPro.
DR CDD; cd01789; Ubl_TBCB; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR045172; TBCB_Ubl.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF14560; Ubiquitin_2; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 188..230
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
SQ SEQUENCE 249 AA; 27715 MW; 8927996D78268551 CRC64;
IRVAPRGLTV VSDPVVTLRI TSTISPFETE KRFMRSITIA EFKGKLEIIV GSPASCMNLA
LFSTDDKFLQ KMDDNDALLG SYHVDNYCKI HVTDTSGQQV DEYNDVSKVQ KVEISDDAYE
KRTDSARSFM KTRKLGHFNE EDMAKKKAEL AAQTEEQKAA ADAISVGSRC KVQVVGQPSK
LGTVMYVGTT LFKPGYWVGV KYDEPLGKNN GTVDGKQYFE CENKYGAFVK PLNVTVGDFP
EEDYGLDEM
//
