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Database: UniProt
Entry: H2TV34_TAKRU
LinkDB: H2TV34_TAKRU
Original site: H2TV34_TAKRU 
ID   H2TV34_TAKRU            Unreviewed;       848 AA.
AC   H2TV34;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 48.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 4 {ECO:0000313|Ensembl:ENSTRUP00000028543};
GN   Name=KCNH4 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000028543};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028543, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000028543}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000028543}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSTRUT00000028657; ENSTRUP00000028543; ENSTRUG00000011301.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140833; -.
DR   OMA; VPKAVWD; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01470; ERGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    396    416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    620    646       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22     90       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      724    824       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   848 AA;  95939 MW;  992642C3F1F82B71 CRC64;
     MPVMKGLLAP QNTFLDAIAT RFDGTHSNFL LGNAQGHRGY PIVYCSDGFC ELTGFTRTEV
     MQKNCGCHFL FGADTSEHVA QQMLKALEGR EEYQAEVYFY KKNGVAFWCL LDIVPIKNEK
     GEMVLFLFSF KDISDMHGRG TEDKRHRRKN GSRFTEARKR GRTMLYHLTS QFSRGGKREV
     NLGGQFQNGC VIVDLCLXPP TLNNTADLLL EQPSALREHT RASAQTQSRM GIFAILIHKP
     PDPAMGPLVS SGPRSSSQKL DSMKQTCHIL HKMVHQSASF LLHVNLAASD FLEKSSSLMN
     QPPHCWPTPF FEGRIVLRWI TAYLSPLAVS LTPVKGNSFF CCHLNVVKAL TCQVHSLIWN
     AALTSMIDKP SMPEYKVAAV QKSRFILLHY SVSKALWDWL ILLATFYVAV TVPYNVSFTP
     YEDTVTAARS TIVSDIVVEM LFILDIILNF RTTYVSQSGQ VVYESRSICI HYVRTWFFVD
     LVAALPFDLL YAFNITVTSL VHLLKTVRLL RLLRLLQKLD RYSQYSAMVL TLLMSMFALL
     AHWMACIWYM IGRKEIETNE TWEIGWLHEL GKRLETPYIN STLGGPTVRS SYIAALYFTL
     SSLTSVGFGN VSANTDAEKI FSICTMLVGG IALMHALVFG NVTAIIQRMY SRRSLYHTRM
     KDLKDFIRVH RLPQQIKQRM LEYFQTTWSV NNGIDANELL HDFPDELRAD IAMHLNKDIL
     QLPVFKGASR GCLRSLSLHI KTSFCVPGEY LIRQGDALHA NYFVCSGSLE VLKDSMVLAI
     LGKGDLIGSD LPGTDQVIKT NADVKALTYC DLQYIGLRGL REVLELYPEY ANVFASDIYN
     NLTYNLRE
//
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