ID H2TVX2_TAKRU Unreviewed; 1004 AA.
AC H2TVX2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 {ECO:0000313|Ensembl:ENSTRUP00000028831.3};
GN Name=LOC101071869 {ECO:0000313|Ensembl:ENSTRUP00000028831.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028831.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000028831.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000028831.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2TVX2; -.
DR STRING; 31033.ENSTRUP00000079033; -.
DR Ensembl; ENSTRUT00000028947.3; ENSTRUP00000028831.3; ENSTRUG00000011416.3.
DR eggNOG; KOG0521; Eukaryota.
DR GeneTree; ENSGT00940000165326; -.
DR OrthoDB; 1449795at2759; -.
DR TreeFam; TF325156; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd13251; PH_ASAP; 1.
DR Gene3D; 1.25.40.950; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR043593; ASAP.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037844; PH_ASAP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45854:SF1; ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45854; ASAP FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 305..397
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 421..543
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 616..648
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 942..1004
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 698..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 111502 MW; F259C21C28780113 CRC64;
MPERISVSEF VVMTNEDLSS PGTSGFQSKM SDCRNTVSVV EESLETDHLT LQKMKKMIKS
IHTSGLSHVE NKEQYIEVLE NLGNSHLTQD NNEVSTGFLN LAVFTREVTA LFKNLVQNLN
NIMAFPLENV LKSELRDSRL ELKKQMEKSW KEYDIKIGKL EKERKEKSRQ LGLIRTEGSD
GGEDMERERR TFQLQMCEYL LKIQELKVRQ GPDLLQSLIK YFQAQLSFFQ DGLKAAENLT
PFIEKLAASV HTVRLDQDEE VKKLTQLRDS LRLLLQVEGK EEYLNRKNSG NGYSIHQPQG
NKKYGTEKSG FLLKKSDGIR KVWQKRKCGV KFGCLTISHS TINRPPAKLN LLTCQVRPNP
EDKKTFDLVT NNRTYHFQAE DEQECLIWVS VLQNSKDEAL NTALVGDQLH LQDSGLQELS
RAIISELRQM PGNDSCADCG APDPTWLSTN LGILTCIECS GIHRELGVHY SRIQSLTLDL
LSTSELLLAV SIGNSRFNDI MEACLPNDSI KPLPQSDMNA RKEYIVAKYA ERRYVMRREE
ADPSRLYDTV RSRDLTSLLQ LYAEGADLSK PLVLPDGQGV KETALHLAVR LEERSSLALV
DFLCQNSNCL EKRTAEGNTA LHYSVLHHKP ESLKLLLKSK ASLHTVNSAG ETALDAARRL
QHLQCVDLLE LAHSGKFNSQ IHVEFMWETH SQEFYDSEDD LDERVSPLPK NRSPLSSNGG
GGSSFACWST NNCPNGGAGS RPCQTYENLE FLYRNPPASS ALSGASAPPP LPAKIIQRGR
SDPQISVTAQ EFTPNPRRSS NPPSHSSPQT QTRNTSSTST ESQGQGGKPP KSPHGQGGLF
RGQKQSCESH TGSQSCIAQN HIGPVSSEKT TSYRRTSSGG GSQGKCSTPS PSCVGSQEEL
YCSLVGSGFT QAPVLAPAQP SSPVQACIPR PRRNAMVSGS RPHHKLVKAL VDCRAVSSEQ
LSFSKDEIIV VTATSDPHWW VGHIEGDPSR SGSFPVNYVH KLTD
//
