ID H2TY35_TAKRU Unreviewed; 383 AA.
AC H2TY35;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Actin-related protein 2 {ECO:0000256|RuleBase:RU365080};
GN Name=actr2 {ECO:0000313|Ensembl:ENSTRUP00000029594.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029594.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000029594.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000029594.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein
CC complex that mediates actin polymerization upon stimulation by
CC nucleation-promoting factor (NPF). The Arp2/3 complex mediates the
CC formation of branched actin networks in the cytoplasm, providing the
CC force for cell motility. Seems to contact the pointed end of the
CC daughter actin filament. {ECO:0000256|RuleBase:RU365080}.
CC -!- SUBUNIT: Component of the Arp2/3 complex.
CC {ECO:0000256|RuleBase:RU365080}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|RuleBase:RU365080}.
CC -!- SIMILARITY: Belongs to the actin family. ARP2 subfamily.
CC {ECO:0000256|RuleBase:RU365080}.
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DR AlphaFoldDB; H2TY35; -.
DR STRING; 31033.ENSTRUP00000067714; -.
DR Ensembl; ENSTRUT00000029711.3; ENSTRUP00000029594.3; ENSTRUG00000011717.3.
DR eggNOG; KOG0677; Eukaryota.
DR GeneTree; ENSGT00940000154556; -.
DR TreeFam; TF300467; -.
DR Proteomes; UP000005226; Chromosome 4.
DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; ACTIN; 1.
DR PANTHER; PTHR11937:SF149; ACTIN-RELATED PROTEIN 2-A; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|RuleBase:RU365080};
KW ATP-binding {ECO:0000256|RuleBase:RU365080};
KW Cytoplasm {ECO:0000256|RuleBase:RU365080};
KW Cytoskeleton {ECO:0000256|RuleBase:RU365080};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365080};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
SQ SEQUENCE 383 AA; 43727 MW; D5ED49E4ACF8306F CRC64;
FYHQLFVKCG YAGSNFPEHI FPALVGRPII RSTAKVGNIE IKDLMVGDEA SELRSMLEVN
YPMENGIVRN WDDMKHLWDY TFGPEKLNID SRNCKILLTE PPMNPTKNRE KIIEVMFETY
QFAGVYIAIQ AVLTLYAQGL LTGVVVDSGD GVTHICPVYE GFSLPHLTRR LDIAGRDITR
YLIKLLLLRG YAFNHSADFE TVRMMKEKLC YVGYNIEQEQ KLALETTVLV ESYTLPDGRV
IKVGGERFEA PEALFQPHLI NVEGVGVAEL LFNTIQAADI DTRAEFYKHI VLSGGSTMYP
GLPSRLEREL KQLYLERVLK GDVDKLSKFK IRIEDPPRRK HMVFLGGAVL ADIMKDKDNF
WLTREEYQEK GVRVLEKLGV TVR
//