ID H2TYH2_TAKRU Unreviewed; 826 AA.
AC H2TYH2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Kirre like nephrin family adhesion molecule 1 {ECO:0000313|Ensembl:ENSTRUP00000029731.3};
GN Name=kirrel1 {ECO:0000313|Ensembl:ENSTRUP00000029731.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029731.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000029731.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000029731.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; H2TYH2; -.
DR STRING; 31033.ENSTRUP00000029731; -.
DR Ensembl; ENSTRUT00000029848.3; ENSTRUP00000029731.3; ENSTRUG00000011778.3.
DR GeneTree; ENSGT00940000155795; -.
DR InParanoid; H2TYH2; -.
DR OrthoDB; 5362512at2759; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF158; KIN OF IRRE LIKE (DROSOPHILA)-RELATED; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..826
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025659216"
FT TRANSMEM 490..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 118..216
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 220..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 306..386
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..483
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 595..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 88942 MW; 0112AB604FB614B4 CRC64;
MQTLLLLSLA LSFQTVLTAR FSQEPADQSV VRGQRVILSC VVFNYTGIVQ WTKDGLALGI
GEDLQAWPRY RVLRVQELGQ YNLEILSAEL SDDSLYECQA PDAALRSRRA KLTVLIPPDD
PVIDGGPEVL LNAGESYNLS CVSRGAKPPS VIEWLKDGLP VEGANSITEV LPDRKRVTTR
SFLPIQPVDT DTGRNYSCTA TNLAVPTGKS TTVTLNVHHP PIVTLSIEPR SVLEGDRVTF
TCQAHANPPI MGYRWAKGGV VLQGARESVF TTKADHSFFT EPVSCLVFNA VGKTNVSILV
DVHFGPILLV EPQPTTVDVD SDVTLNCKWA GNPPLTLTWF KKGSNMVLSN SNQLYLKSVS
QADAGQYVCK AIVPRIGVGE TEVALTVNGP PIISSDPVQY AVRGERGEVK CYIASTPPPD
NIVWAWSENV QERYTVKSKP STEGGGVLST LTINNVMESD FLSTYNCTAW NSFGPGTMII
TLEAMDEVPV GIIAAGTVGS TIILFIFLLV LVLIFYRQRK GSRRGVTLGK PDIKVETINK
ETHSLEEDSG SVSTASRMVK AMYSFLPSVS FSPSNQPFKD EIELKTDLRS DTLDTRQEYD
LKDPTNGYYN VRASTHDEGR PASGSTMHYS DYRSPAGTPG GAASISSSTG GSGATASGGA
PVPPGPLTSP GRPQACYDPR PPSRLSHISY AQFNTFTRGG QSQQPPANPA PVAADFPGDC
SLMDSTSQLA YDNYGYPSHY QTYRMGFAPS SLAPLEAGPS YEMYGVGSGV GPGLASHGVG
VGPAAPAPPR SETGLGKYGS STRFSYTSQH SDYSHSRHTQ RMQTHV
//
