ID H2TYP4_TAKRU Unreviewed; 387 AA.
AC H2TYP4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=XK-related protein {ECO:0000256|RuleBase:RU910716};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029803.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000029803.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000029803.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU910716}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU910716}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000256|ARBA:ARBA00008789,
CC ECO:0000256|RuleBase:RU910716}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2TYP4; -.
DR Ensembl; ENSTRUT00000029920.3; ENSTRUP00000029803.3; ENSTRUG00000011802.3.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT01090000260093; -.
DR HOGENOM; CLU_028534_2_1_1; -.
DR InParanoid; H2TYP4; -.
DR OMA; LWFWKMS; -.
DR TreeFam; TF316454; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018629; XK-rel.
DR PANTHER; PTHR16024; XK-RELATED PROTEIN; 1.
DR PANTHER; PTHR16024:SF19; XK-RELATED PROTEIN; 1.
DR Pfam; PF09815; XK-related; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910716};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|RuleBase:RU910716};
KW Transmembrane helix {ECO:0000256|RuleBase:RU910716}.
FT TRANSMEM 14..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 45..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
FT TRANSMEM 310..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910716"
SQ SEQUENCE 387 AA; 44606 MW; 02176EF00AAA4F88 CRC64;
RGVMGVFSYS PWDFVFTCLG LLFLLLDIGL DILALVTFYQ EKSHVCLGLL LLFLLGSSVL
VQAFSWLWYS YENFSRHTRV EKCPSPGQLL LLHVLQLGIY FRLCTRSSRL QAGIFLAEQQ
GSHGDNAVFL SHDLSMLRLI ETFSESAPQL VLMLTIILQR ASAIAFSVTM YHRSLRSFLP
DKKQQNMASS VVYFLWNVIL IASRLTALAL FASLLPCFIF AHFICSWLLF FFFVWRSKTD
FMDSPGGEWL YRATAGLIWY FDWFNVVEGR TRYRTLLYHG YMLADISLLC ALWCWRTTAT
EQPYFELSPL QAVITAVSVV ACYILGLFIK MIYYRRFHPN LHKEELKGST VDQDEVDSND
VFRSIPQASG GNHCNKRMRI LAENFYT
//
