ID   H2TYZ7_TAKRU            Unreviewed;       458 AA.
AC   H2TYZ7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Sorting nexin 2 {ECO:0000313|Ensembl:ENSTRUP00000029906.3};
GN   Name=SNX2 {ECO:0000313|Ensembl:ENSTRUP00000029906.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029906.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000029906.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000029906.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H2TYZ7; -.
DR   Ensembl; ENSTRUT00000030023.3; ENSTRUP00000029906.3; ENSTRUG00000011833.3.
DR   GeneTree; ENSGT00940000155798; -.
DR   Proteomes; UP000005226; Chromosome 21.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR015404; Vps5_C.
DR   PANTHER; PTHR10555; SORTING NEXIN; 1.
DR   PANTHER; PTHR10555:SF31; SORTING NEXIN-2; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF09325; Vps5; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   DOMAIN          103..232
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          399..433
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   458 AA;  51606 MW;  0780C910A7292E84 CRC64;
     MSSQSGPASL PAEDISTNAN GPRQDSLFDD DPEDLFAEAT EEVSLDSPER DVLLSDGPSP
     AITPITPPTS VITPCIGITH DDMFTHSSFD EVNTLCSEIN VELLILTPVS HLCVSGDGMN
     AYMAYKVTTK TSMALFKNKD FSVKRRFSDF LGLHSKLASK YLHVGYIVPP APEKSIVGMT
     KVKVGKEDQS SNEFVEKRRS ALERYLLRTV KHPILLKDPD VLQFLESSEL PRAVNTQALS
     SAGLLRMVNK AADAVNKMTI KMNESDAWFE EKQQHFENLD NQLRKLHASV ESLVCHRKEL
     SVNTAQFAKS AAMLGNSEDH TALSRALSQL AEVEEKIDQL HQEQANADFY LFSELLGDYV
     RLITAVKGVF DHRMKTWQKW QDSQLLLQRK REAEAKLQFN NKPDKLQQAK DEIKELEGKV
     EQGERDFEQI SKTIRKEVSR FELIKYWEAF LPEAKAIS
//