ID H2TZD8_TAKRU Unreviewed; 681 AA.
AC H2TZD8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=RNA-binding protein MEX3B-like {ECO:0000313|Ensembl:ENSTRUP00000030047.3};
GN Name=LOC101079853 {ECO:0000313|Ensembl:ENSTRUP00000030047.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000030047.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000030047.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000030047.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2TZD8; -.
DR Ensembl; ENSTRUT00000030164.3; ENSTRUP00000030047.3; ENSTRUG00000011888.3.
DR GeneTree; ENSGT00940000160013; -.
DR HOGENOM; CLU_025598_2_0_1; -.
DR InParanoid; H2TZD8; -.
DR OMA; MECANSI; -.
DR OrthoDB; 50983at2759; -.
DR Proteomes; UP000005226; Chromosome 21.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22423; KH-I_MEX3_rpt1; 1.
DR CDD; cd22424; KH-I_MEX3_rpt2; 1.
DR CDD; cd16518; RING-HC_MEX3; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047228; KH-I_MEX3_rpt1.
DR InterPro; IPR047226; KH-I_MEX3_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047227; MEX3.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23285; RING FINGER AND KH DOMAIN CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23285:SF8; RNA-BINDING E3 UBIQUITIN-PROTEIN LIGASE MEX3C; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 629..668
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 71118 MW; F14DE43B1B2A18B5 CRC64;
MPSSTSLVEA EEGESEVPPP LVHAFAGMGL EEHHGSQSQT PEQTDEGLPH HHYHFPSVSH
FNFLGTVLDL KPLHRPSSAD EGAITAAPED EEQEVGGDSS SSGSSLLAQA HVNRHLQSGP
GCSMVPSGLE TPQVETVLLY NGDDRDDGVL GGSSLPPNGS MVLVPSGVYG EFGFEAEPSL
LNRRKSVNTT ECVAVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE QPVFVVTGRK
EDVAMAKREI LSAAEHFSLI RASRNKAGPL AAATGPGNPS LPGQTTIQVR VPYRVVGLVV
GPKGATIKRI QQQTHTYIVT PSRDKEPVFE VTGMPENVDR ARDEIEAHIA LRTGSCGGIE
APGADNNDFQ FNGTDVSFDG SAASAGLGEG AWPLAGVASQ GGGGLLPVSV SGTQQINSNM
TSGVRMSSTY RNDSSSSLGS GSSSVDSVYG GGSGNRVADL SPTCVFNANN NNNNNGGSAS
FWFGESLLPV GSEELVSLGG GGSSSGFDPL TISTGQATLS GVQPPIWSPF VDHQPLQAFE
ARQSQTSQPG TPRLSPIISG TEALEHPQAR RVTRAPLASV GNLDAHRFPS YSSTFSSSGE
STASSSSPPE SFLSYRPGQG SVVRGQEICI QCMDNQVIAA LVPCGHNLFC LDCATLICQG
PDAVCPVCLS PVTQAIKLRN M
//
