ID H2U1X4_TAKRU Unreviewed; 360 AA.
AC H2U1X4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Tyrosyl-DNA phosphodiesterase 2 {ECO:0000256|ARBA:ARBA00017870};
DE AltName: Full=5'-tyrosyl-DNA phosphodiesterase {ECO:0000256|ARBA:ARBA00031304};
GN Name=LOC101065077 {ECO:0000313|Ensembl:ENSTRUP00000030935.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000030935.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000030935.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000030935.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}.
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DR AlphaFoldDB; H2U1X4; -.
DR STRING; 31033.ENSTRUP00000030583; -.
DR Ensembl; ENSTRUT00000031053.3; ENSTRUP00000030935.3; ENSTRUG00000026060.1.
DR eggNOG; KOG2756; Eukaryota.
DR GeneTree; ENSGT00390000014242; -.
DR HOGENOM; CLU_047318_1_0_1; -.
DR InParanoid; H2U1X4; -.
DR OMA; AENDWDM; -.
DR OrthoDB; 276861at2759; -.
DR TreeFam; TF314813; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd09080; TDP2; 1.
DR CDD; cd14344; UBA_TYDP2; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15822; TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR15822:SF4; TYROSYL-DNA PHOSPHODIESTERASE 2; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 115..350
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 72..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 40967 MW; 39783348D10306CB CRC64;
MASTSNSETA STAIEENRIR LCEEFAKIAE TDVAVAQCYL AMNEWEMERA LNSFFEAEME
KVFEVENQAE NEACPKTKRQ RSEENPTTDC IDLTENSPTS SDKPSEDDDK KLSLITWNVD
GLDTDNLADR ARGLCSFIVL YTPDVVFLQE LIPAYVQYLK KRAVSYLIIE GGDEGYFTGM
MLKKTRVKLL ESEIVTYPTT QMMRNLLVAQ VDFRGQKLCL MTSHLESCKG HAEERMKQLR
VVMQRMRDAA EDVTVLFGGD TNLRDPEVTK VGLPPNVCDV WEQLGKQEHC RYTWDTKANS
NKTVPYVSRC RFDRVYFRPA TTDGVPRLAP DHMALVGLEK LDCGRYTSDH WGIYCSFSVG
//
