ID H2U285_TAKRU Unreviewed; 630 AA.
AC H2U285;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=FAST kinase domain-containing protein 4 {ECO:0000256|ARBA:ARBA00040471};
DE AltName: Full=Protein TBRG4 {ECO:0000256|ARBA:ARBA00043220};
DE AltName: Full=Transforming growth factor beta regulator 4 {ECO:0000256|ARBA:ARBA00042265};
GN Name=TBRG4 {ECO:0000313|Ensembl:ENSTRUP00000031046.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031046.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031046.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031046.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the FAST kinase family.
CC {ECO:0000256|ARBA:ARBA00038281}.
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DR AlphaFoldDB; H2U285; -.
DR STRING; 31033.ENSTRUP00000031046; -.
DR Ensembl; ENSTRUT00000031164.3; ENSTRUP00000031046.2; ENSTRUG00000012262.3.
DR GeneTree; ENSGT01030000234607; -.
DR HOGENOM; CLU_029448_0_0_1; -.
DR InParanoid; H2U285; -.
DR OMA; NFNHSQV; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IEA:InterPro.
DR InterPro; IPR013579; FAST_2.
DR InterPro; IPR010622; FAST_Leu-rich.
DR InterPro; IPR013584; RAP.
DR PANTHER; PTHR21228:SF59; FAST KINASE DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR21228; FAST LEU-RICH DOMAIN-CONTAINING; 1.
DR Pfam; PF06743; FAST_1; 1.
DR Pfam; PF08368; FAST_2; 1.
DR Pfam; PF08373; RAP; 1.
DR SMART; SM00952; RAP; 1.
DR PROSITE; PS51286; RAP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 560..618
FT /note="RAP"
FT /evidence="ECO:0000259|PROSITE:PS51286"
SQ SEQUENCE 630 AA; 70316 MW; AAEB682CB8E2B8DC CRC64;
MAGRLMGRCA RLLCRASCQA PAVARLPLTV AGPAEVRRAP AWQWTTERLM CEGSTNVKED
ILSNMPTQTR LDNLLDKATV PEDVLLAWAE HGRNSNQAAC ALIKYTQLLM RMKGRHSNVV
LTCLNAFPVC FFLQVSLVWN GTLVNVLRSL WTIDSPSTKS LLSSVQTEVL WRVRRLSYKQ
LGHLIDWGSG KTSPQDAAIV NAVLKQLELR WIEIADSKTL SMLISNGKIM SPTLMDRLED
KALELSENFT AEEIRKVCVS LAVQRRRSVP LLRALSYHLL QKPPSDFTTE LMLDMAFAYG
NSKNVQNTQL SPHSNGLRVG TEGSSAQPRR CRLSSDCWFS PPSPPMFDSP PTLFHQHYTA
KSQNYSTAQL CNLLMAFARL NFQPSKREEF FSKVHPALVD ALPAMEPLLL TDVVWSLCVL
QQARPQYLIP LMQESHVSKL SGKEPRVENY QLKLLHIAAT LQLEFPGSTD PSPCLSSLSV
PGTSSTVTPM QSSLRETLQS LVEGKTEALR TGVSTVYGWT IEGELVVDYD NKPVGLTTLK
APHLPSGGGA QFLPEGARRL AFLAWEFPNF CSKSRDLLGR FAMMKRHLQL AGFITVEVPY
YEWLELKTDR QKVAFLKDKI GKAVAEDMAK
//
