ID H2U328_TAKRU Unreviewed; 1670 AA.
AC H2U328;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Neurexin-2-like {ECO:0000313|Ensembl:ENSTRUP00000031339.3};
GN Name=NRXN2 {ECO:0000313|Ensembl:ENSTRUP00000031339.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031339.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031339.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031339.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 31033.ENSTRUP00000031339; -.
DR Ensembl; ENSTRUT00000031461.3; ENSTRUP00000031339.3; ENSTRUG00000012376.3.
DR GeneTree; ENSGT00940000155978; -.
DR HOGENOM; CLU_014484_0_0_1; -.
DR InParanoid; H2U328; -.
DR OMA; XHAGIGH; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1670
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025537845"
FT TRANSMEM 1595..1615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..201
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 197..235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 250..447
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 454..646
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 650..687
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 690..864
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 878..1053
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1056..1093
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1097..1297
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1469..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1637..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1498..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1637..1653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1654..1670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1670 AA; 184130 MW; 0E4321C1A8B89FF5 CRC64;
MTRGLRFLCW PLWPLSFSLL TTVQMLEFGG APGQWARYGR WEAGSEGELS FSVRTNVSKA
LVLYLDDAGN CDFLELLIAA GRLQLRFAIH CTEPATVQMA TRVNDDRWHM VLLTRNFRET
LLMVDGETKV AEVKSKRKEM AVVSDLFVGG IPPDVRLSTL TSSTVKYEPP FQGLISNLKV
GAIPPTLLNS HGIQTESEYL CTKQNPCFNG GFCSVQYGEV HCDCTHTRFR GKYCKEGLAH
LTLNDQGMSV ATFKGNEFFC YDLSLTPIQS STDEITLSFR TLQRNGLMLH TGKSADYVNL
SLKSGAVWLV INLGSGAFEA LVEPVNGKFN DNAWHNVRVT RNLRQHAGIG HAMVNKLHYM
VTISVDGILT TTGYTQEDYT MLGSDDFFYI GGSPNTADLP GSPVSNNFMG CLKDVVYKNN
DFKLELSRLA IERDPKITLH GDLVFRCEDV AALDPVTFDT PESYISLPKW NTKKTGSISF
DFRTTEPSGL LLFSHGRPQG PKEQKPGREL KTDYFAMELL DGYLYLLIDM GSGKTKLKAN
NKKVNDGDWC HVDFQREGRK GSISVNSRSI PFNSPEGSEI LDLDSDMYLG GLPELKSDLI
LPPEVWTALL NYGYVGCVRD LFIDGKSRDV RRLAEIQSAI GVSSFCTREL QKRCSSTPCA
NGGLCKEGWN RYICDCTGTG YLGSNCEIEA TVLSYDGSMY LKIIMPVTMH TEAEDLSLRF
MSQRAYGLLM ATTSKESADT LRLELDGGRI KLTVNLDCIR IDCSLSKGPE MLFAGQKLND
NEWHTVKVVR RGKSLQLSVD NVTVEGQMTG AHTRLEFHNI ETGIMTERRF ISMVPSNFIG
HLQGLSFNGV PYLDQCKNGD ISYCELNARF GMRHIIADPV TFRTKGSYLA LATLQAYASM
HLFFQFKTTT PDGLILFNSG DGSDFIVVEL VKGYVHYVFD LGNGPSLMKG NSDKPLNDNQ
WHNVVVSRDA NNVHTLKIDS RTVTQHSNGA RNLDLKGELY IGGVTKNMYS NLPKLIASRD
GYQGCLASVD LNGRLPDLIA DALHRVGQVD RGCDGPSTTC TEESCYHQGV CLQQWEGFTC
DCTMTSYGGS FCNDPGTTYI FGRGGALITY TWPPNDRPST RADRLAVGFS TQLKEAILVR
VESAKGLGDY LELHIERGKI GVIFNVGTDD IIIEESAVMV SDGKYHVVRF TRSGGNATLQ
VDNQPVIERF PSGNFDNERL AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAFIKIGGG
EKGRHFQGQI SGLYYNGLQV LKLAAEGDPN VQTQGNLRLV GDVPSVLTTD TTSTTPLADM
STTIMETTTT MATTTTRKQR SPTMRDSVTQ NADDLLVASA ECPSDDEDLE ECEPGNGGEL
VLPIITVDSL DPPSIATRYP VIPPPPTTYR PFLTLLETTK ESLPLPNGRP PCPLDQEDCE
ETIEVSAYGS GEMTESDDED YYKKFPLVTD RTVLPPPPAA EGGVQNPRDR HFSRVPNSHR
PPLSSTPTAN PDQLSPHLKP VAGGSSSNKI PAGKMNTRDQ VLLPPAHPSD PGNRRVPGIT
YPPNFPHVPT PDPTSPDGGL PGAVEVQQSS STTGMVVGIV AAAALCILIL LYAMYKYRNR
DEGSYQVDQS RNYISNSATQ SNGALVKEKQ PSTAKTVTKN KKNKDKEYYV
//
