ID H2U3R0_TAKRU Unreviewed; 442 AA.
AC H2U3R0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Vitronectin-like {ECO:0000313|Ensembl:ENSTRUP00000031571.2};
GN Name=LOC101063812 {ECO:0000313|Ensembl:ENSTRUP00000031571.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031571.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031571.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031571.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003971087.1; XM_003971038.2.
DR AlphaFoldDB; H2U3R0; -.
DR STRING; 31033.ENSTRUP00000067819; -.
DR Ensembl; ENSTRUT00000031694.3; ENSTRUP00000031571.2; ENSTRUG00000012463.3.
DR GeneID; 101063812; -.
DR KEGG; tru:101063812; -.
DR CTD; 403026; -.
DR GeneTree; ENSGT00530000063751; -.
DR OrthoDB; 5310951at2759; -.
DR Proteomes; UP000005226; Chromosome 15.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 2.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR018486; Hemopexin_CS.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF3; VITRONECTIN; 1.
DR Pfam; PF00045; Hemopexin; 2.
DR Pfam; PF01033; Somatomedin_B; 1.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 4.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS00024; HEMOPEXIN; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 4.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..442
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017318543"
FT DOMAIN 20..62
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 121..165
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 166..213
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 214..274
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REPEAT 374..425
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 68..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 50555 MW; 4125E7FE62A65C02 CRC64;
MKLGVVLLSL VLLLDKVFAA EESCVGRCGS FNPRSKCQCD SMCTYYESCC VDFYTICPKK
ISRGDTFSET EEVTEAATTP PETTAAPTVG TLAATTPTPL TPNTPDPTFL PVDAHAAPCS
GRPFDAFLQL KNTSIYAFRG EYFFELDEKS ILPGYPKLIQ DVWGIPGPID AAFTRINCHG
KSYIFKGSQY WRFDGDVMDE DYPRNISVGF GDVPDGVDAA FAVPAPSHRG KEKAYFFKED
RYYQYEFKHQ PSHEECVEMN KASPSILFRR YNDLFCDQTW EDLFTELFGG PVSSHHLGPR
QTSQDWGIRP PVDAAMVGKV FLGPKPTSPP PARRRSNRRR KPSRRRTQRR RQSRFVYLYD
LWDYDYWFGD YSTEGTTKQK HQSTPVQNVY FFMKDKYYRV DLQTKRVDSA IPPYPRSIAK
YWLGCEAEEP FDAPRAEKKH SF
//
