ID H2U487_TAKRU Unreviewed; 774 AA.
AC H2U487;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSTRUP00000031749.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031749.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031749.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031749.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR AlphaFoldDB; H2U487; -.
DR STRING; 31033.ENSTRUP00000068715; -.
DR Ensembl; ENSTRUT00000031872.3; ENSTRUP00000031749.3; ENSTRUG00000012539.3.
DR eggNOG; KOG3716; Eukaryota.
DR GeneTree; ENSGT01060000248595; -.
DR HOGENOM; CLU_013513_2_1_1; -.
DR TreeFam; TF313836; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF114; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..47
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 179..749
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 478
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 774 AA; 88413 MW; DA32C2428C2C2584 CRC64;
MAEAHQAVGF EFTVIPEGAD AQLSHQALTE IYLSAVNSWK KCIIRIKNSV IRGVYPASPF
SWLFVVIAIL ATMYTRSDPS MGLIAKIQEN LPFFFYCFSL NSDTQCKVLL SAVIFSTMLW
LLLIFTMRLC LKQLLSYHRW MFEPHGKMST TTKVWVALVR IFSGRKPRLY SYQASLPNLP
VPAVKDTVKR YLESVRPLMD DAQYEHVTKL AAEFESSLGN RLQWYLKLKA LWVTNYVSDW
WEEYVYLRGR NPIMVNSNYY VMDFLYVTPT PIQAARAGNT IYAMLLYRCK LNKEEIKPVG
SALGTFPCCS YQFERMFNTC RIPGTLTDTI QHWKDSDFIV VYHKGRYFQL YVYQDGRLLC
PREIEFQIQR ILDDPSPASK GEARLGALTA GDRIPWAKAR AKHFNSGINK KSLDCIEKAA
FFVTLDDEEQ SIVGDNLGES LDCYIKSLLH GKCYNRWFDK SFSVVFYKNG KSGLNGEHSW
GDAPVLTHLW EYTLATECFQ LGYNAEGHCK GEVDASLAEP QKLNWEISSE CEEQISQSLE
VAQALANDVD MHVVVFRDFG KAKVKKCRVN PDAFIQIALQ LAYYRDQKRF SLTYESSMTR
LFREGRTETV RSCTNESCAF IRALEGGETT DVCRRLFRTA SEKHQRLCRM ASTGAGIDRH
LFCLYVVSKC LGVESPFLKE LESEAWRLSS SHIPYQMIDL FDTVNHPEYL CYGGGFGPVT
DDGYGVCYLM LGGDVLTLHI SCKNSCPDTV IFYHLKAAFY DLGSLRLPSL PMFL
//
