ID H2U551_TAKRU Unreviewed; 833 AA.
AC H2U551;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Rho GTPase activating protein 42b {ECO:0000313|Ensembl:ENSTRUP00000032064.3};
GN Name=ARHGAP42 {ECO:0000313|Ensembl:ENSTRUP00000032064.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032064.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000032064.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000032064.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2U551; -.
DR Ensembl; ENSTRUT00000032187.3; ENSTRUP00000032064.3; ENSTRUG00000012664.3.
DR GeneTree; ENSGT00940000155492; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 231..340
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 342..538
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 775..833
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 592..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 94794 MW; 500DF31BDD3C6C8B CRC64;
MGLPTLEFTD SFLDSPDFRE RITCHEIELE RTNKFIKELI KDGNMLIAAF RNLSVAVQKF
SQSLQEFQFE CIGDAETDDE VNIAQSFKEF SQLLNMVEEE RRRLIQNADD VLITPLEKFR
KEQIGAAKAD TQIDKERQLF YDASLEYVFK IQEVQEKKKF EFVEPLLAFL QGLFTFYHEG
YELAHEFEPY KQQLQFNLQN TRNNFVSTKQ EVEKLMKRIR SADQDYKPPG QWTMEGFLYV
QEKRPLGCTW TRHYCTYDKG SNTFTMSNTD TKSAAKQNGV VLNQPEIFKL KSCIRRKTDS
IDKRFCFDIE VVERHGVMTL QALSESNRRL WLEAMDGKEP IYNLPAILSK KEETFLNEAG
FNFVRRCINL VEVRGINTMG LYRIGGVNSK VQKLMTTVFS SKAPVDMDLN AEMWDNKTIT
SGLKNYFRCL SEPLMTFKLH KDFIMAVKSD DQNYRVCAVH ALVHKLPERN KEMLELLIQH
LVTVSTQSQL NLMTVSNLGV IFGPTLMRSQ EETVAAMMNI KFQNIVVEIL IENFNKIFHQ
PPDANVPLPQ PQSRPDSRRN RAICLSTGPR KPRSLYTPTL CLADAESNSS PCSTPMGSLE
SLSSHSSEQN NSSKMAPSAQ VMNKSLFHQT PSKLSNGYRS ATGMSTLESS SREEAERTDV
ELEDNCSLSS FSVTPRLSSA PKKAPHCRSD LSLALMHHPD PPSMKSLYLS EGPMKSSGSV
HSLSTLEPKV DLKPEQPDHP AKQPVPHRLE TSFYNGYQRP GSVVAARAHR FENASTGQDA
KAMYSCEAEH SHELSFPQGA HFTNVYASVE PGWLQATYEG RTGLIPENYV VFL
//
