ID H2U5H6_TAKRU Unreviewed; 581 AA.
AC H2U5H6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Immunoglobulin like domain containing receptor 2 {ECO:0000313|Ensembl:ENSTRUP00000032192.3};
GN Name=ildr2 {ECO:0000313|Ensembl:ENSTRUP00000032192.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032192.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000032192.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000032192.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. LISCH7 family.
CC {ECO:0000256|ARBA:ARBA00009491}.
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DR AlphaFoldDB; H2U5H6; -.
DR Ensembl; ENSTRUT00000032316.3; ENSTRUP00000032192.3; ENSTRUG00000012720.3.
DR GeneTree; ENSGT00950000183058; -.
DR HOGENOM; CLU_028969_1_0_1; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR008664; LISCH7.
DR PANTHER; PTHR15923:SF0; IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING RECEPTOR 2; 1.
DR PANTHER; PTHR15923; TRANSMEMBRANE AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05624; LSR; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025693836"
FT DOMAIN 35..159
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 329..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 581 AA; 65747 MW; 6D584F8C7AF29816 CRC64;
MNFYRLALLL GASVCMCNGV HVTVREKQRY AMLFQSVVLP CQYQTASSQA AVVQWWYKSY
CRDRTKESFT LPETLAIQTS ELGATSHLEC SDTSRTVRVV ASAQGASLTL AEHYKGRDIT
IINKADLRIG ELQWGDSGVY FCKVVIADDL EGKNEAQLEL LVLGRTGQQD DLLPEFDVEI
MPEWAFVASV VLGSFLFLLL LGICWCQCCP HSCCCYVRCC CCPDTCCCPR HLYEAGKMAK
RGPPAQVPVY PYYIPGVPAV VPLAPSSHVE PKITSIPSVE TNLAGASSMS ELSSLHDGGN
TDFRHTYQTV QMKALPPIAD LDDLSLRAAP PRQSHRLRRD RGNHSDDELD RRWNSRSEHL
DRKTLSRRGR TGSLDELEDF ACSFSSRGRR ALSRGYERDY SPPRRSFRDE VDEWSRRSPS
PLPQKRRDTW DSDRHWQPSH SREYDGTFLN SALEHKARAR GGERGAPRLD EDSDTPSKGS
SRGKGSYYSR SPSNRPEEED PLPPYSEWEA ERHYRAEANT ERYRTVDAPR SGRYRTTESH
MRPFSYTRPP QGASHTLQGG REERDRNRNL STALSRDSLI V
//
