ID H2U8E4_TAKRU Unreviewed; 897 AA.
AC H2U8E4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=FERM domain containing 4A {ECO:0000313|Ensembl:ENSTRUP00000033210.3};
GN Name=frmd4a {ECO:0000313|Ensembl:ENSTRUP00000033210.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000033210.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000033210.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000033210.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2U8E4; -.
DR STRING; 31033.ENSTRUP00000083546; -.
DR Ensembl; ENSTRUT00000033336.3; ENSTRUP00000033210.3; ENSTRUG00000013081.3.
DR eggNOG; KOG3529; Eukaryota.
DR GeneTree; ENSGT01020000230354; -.
DR TreeFam; TF328984; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13191; FERM_C_FRMD4A_FRMD4B; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR021774; CUPID.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR047176; FRMD4A/B.
DR InterPro; IPR041785; FRMD4A/B_FERM_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46079; FERM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46079:SF3; FERM DOMAIN-CONTAINING PROTEIN 4A; 1.
DR Pfam; PF11819; CUPID; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 17..307
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 350..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..559
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 99936 MW; 1646EE0A81F78427 CRC64;
MSLIYISFFN SQMTEGRRCQ VHLLDDRKLE LLVQPKLMAK DLLDLVASHF NLKEKEYFGI
AYTDETGHFS WLQLDRRVLE HEFPKKSGPI VLYFCVKFYI ESISYLKDNA TIELFFLNAK
SIIYKELIEV DSDVVFELAS YILQKTFPTC FPLHLFPSIV AFVLLSYSED RVIEHYKKLS
GQSRGQAIVN YMSIVESLPT YGVHYYAVKD KQGIPWWLGL SYKGIFQYDH QDKVKPRKVF
QWRQLENLYF REKKFSVEVH DPRRASVTRR TFGHSGIAVH TWYACPALIK SIWAMAISQH
QFYLDRKQSK SKIHAARSLS EIAIDLTETG TLKTSKLANM GSKGKIISGS SGSLLSSGSQ
ESDSSQTAKK DMLAALRARQ EALEETLKQR IEELKSICIR EAELTGKLPK EYPLDPGEEP
PTVRRKIGTA FKLDEQKILP KGEEEELERL EREFAIQSQI TEAARRLASD PHVNSKKLKK
QRKTSYLNAL KKLQEIENSI NEYRVRSGKK PTQRASLIIE GIFHPSDDPQ VTGTPTFSPV
ASPHKGLPPR PPSHSRPPPP QSLDGLRHMH YTRSDYDKSP IKPKMWSESS LDEPYEKVKK
LDISPTRLHS LAQHFRNRSS SLESQGKLLA SDSDAHPHAL GTLGSPDFFL GPGRSSNGSD
PLDDCSSCTS QSSSEHYYPS GGPPGSNPNY STLGEDSPSK ARQRQRQRHR SAGHLGSSNS
GSMPNLAAKN GTGGCSGSQP SSQYRIKEYP LYVEGSPNPV VVRSLESDQE GHYSVKAQFK
TSSSYTAGGL YKEAWGGDEG GEGSGRLTPS RSQIVRTPSL GREGGGSGGR AAVSEELRCW
YQRSSGSLKD RNHSHSGSTS SETGSQQGTL GHGRGSRVGT LAKSSPGGSF LTLTLVS
//
