ID H2U9D9_TAKRU Unreviewed; 825 AA.
AC H2U9D9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSTRUP00000033555.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000033555.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000033555.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000033555.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H2U9D9; -.
DR STRING; 31033.ENSTRUP00000062186; -.
DR Ensembl; ENSTRUT00000033681.3; ENSTRUP00000033555.3; ENSTRUG00000013189.3.
DR GeneTree; ENSGT01060000248588; -.
DR Proteomes; UP000005226; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF7; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 4.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..247
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 825 AA; 93971 MW; 83F6AF969B76C9FE CRC64;
LHRTGLLTLC HIQAFRGAGY LSRTQSARYL LKTEDHFLDA AENGNVPKVV QMLAELPDLN
VNYVNCKGQN ALQLAVANER LEVTKRLLKK KDLTRIGDAL LLAISKGYVR IVEALLSHQA
FLDGQRLSDC LSQSDDDFFT FDEDGTRFSR DITPIILASQ CHQYEMVHIL LMKGARIERP
HDYFCQCRAC SDEQSRDSFS HSQSRINAYK GLASPAYLCL SSEDPVMEAL ELGNELSILA
NTEKEFKNDY TNLSTQCKDF VVGLLDLCRN TEEVKAILNG DAESCQNADT SCRQNLYRLK
LAIRYEVKKF VAHPNCQQQL LSIWYEDLSG VRQQNTAVKI LLVLGVAAGL PVLAFIYWLA
PSSKLGKLMH GPFLKFVAHA ASFIIFLCLL VLNGIDRFGG TSLLPNMTTR DHPLQLFRMK
TTPFTWMEIL IISWVTGNIW KGCKEIWVQD IGEYMSEPWN LLDFSILATF MASFIARLMA
FWHAYSAQCY IDKHYSDLAN MNLPFEIQYF QLARIDWLPS DPQLISEGLY AVAVVLSFSR
IAYILPANES FGPLQISLGR TVKDIFKFMV IFTTVFVAFM VGMFSLYSYY LGVKYNNAFT
TIEESFKTLF WAIFGLSEVK SVVINIDHKF IENIGYVLYG VYNIIMVIVL LNMLIAMFNS
SFQEIQGDAD VEWKFARAKL WFAYFEHCST LPVPFNLIPT PNSVLSLWLG IRDSLWNRPQ
SNSQHSSNDV VFQVNRFLTE ATLGPTHYQK IMNRLVKRYI LKAQSDKENS QVNEGELKEI
KQDISSLHYE LAERGSSDAE KLANLIRHLD QVMQKKGAQG PQKRV
//
