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Database: UniProt
Entry: H2UBT5_TAKRU
LinkDB: H2UBT5_TAKRU
Original site: H2UBT5_TAKRU 
ID   H2UBT5_TAKRU            Unreviewed;       509 AA.
AC   H2UBT5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-JUN-2018, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034403, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000034403}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000034403}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   Ensembl; ENSTRUT00000034529; ENSTRUP00000034403; ENSTRUG00000013490.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    239    263       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    284    301       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    313    337       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    441    466       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   509 AA;  58289 MW;  5D2A8063F3E3F963 CRC64;
     MFSSSCSFVS GIIQRVKIEA FERMLWRVCK GYTILTHAEV EEYLENPDTG EPTKSVVFLI
     SYWGDQIGQK VKKICDCYHC HLYPYPSSNE ERNDVLEGLK TRIQDLHTVL HRTEDYLRQV
     LIKASESIYT WIIQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVNDIPK LRRALEEGSR
     KSGATVPSFV NRIPTNNTPP TLIRTNKFTS GFQNIVDAYG VGSYREVNPA PFTIITFPFL
     FAVMFGDLGH GLIMALFASW MVLYENNRKL KNTRNEIWNM FFEGRYLIHF INMFLMQGRG
     MQPLYPGQNG LQIFLVVIAV LSVPVLFLGK PLYLYWLHNG NQHGYERVRH DSDEELFLLS
     AHNMEEGSSH SDLSSSGDHE PENFNFADEL LHQAIHGIEY CLGCISNTAS YLRLWALSLA
     HAQLSEVLWS MVMRVGLRMD ISLGILFLVP VFGLFAVLTV SILLVMEGLS AFLHALRLHW
     VEFQNKFYSG NGVKFYPFSF SLLPSSLES
//
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