ID H2UCP5_TAKRU Unreviewed; 502 AA.
AC H2UCP5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Prenylcysteine oxidase 1 like {ECO:0000313|Ensembl:ENSTRUP00000034714.3};
GN Name=PCYOX1L {ECO:0000313|Ensembl:ENSTRUP00000034714.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034714.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000034714.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000034714.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR036292};
CC -!- SIMILARITY: Belongs to the prenylcysteine oxidase family.
CC {ECO:0000256|ARBA:ARBA00009967, ECO:0000256|PIRNR:PIRNR036292}.
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DR AlphaFoldDB; H2UCP5; -.
DR STRING; 31033.ENSTRUP00000034714; -.
DR Ensembl; ENSTRUT00000034841.3; ENSTRUP00000034714.3; ENSTRUG00000013590.3.
DR GeneTree; ENSGT00390000011206; -.
DR HOGENOM; CLU_021176_1_0_1; -.
DR InParanoid; H2UCP5; -.
DR OMA; NMWAVEG; -.
DR Proteomes; UP000005226; Chromosome 15.
DR GO; GO:0001735; F:prenylcysteine oxidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030328; P:prenylcysteine catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010795; Prenylcys_lyase.
DR InterPro; IPR017046; Prenylcysteine_Oxase.
DR PANTHER; PTHR15944; FARNESYLCYSTEINE LYASE; 1.
DR PANTHER; PTHR15944:SF2; PRENYLCYSTEINE OXIDASE-LIKE; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR Pfam; PF07156; Prenylcys_lyase; 1.
DR PIRSF; PIRSF036292; Prenylcysteine_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRNR:PIRNR036292};
KW Flavoprotein {ECO:0000256|PIRNR:PIRNR036292};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036292};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..502
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025560643"
FT DOMAIN 129..491
FT /note="Prenylcysteine lyase"
FT /evidence="ECO:0000259|Pfam:PF07156"
SQ SEQUENCE 502 AA; 55509 MW; 4EE8240B15538A11 CRC64;
VTMSVSFLSL LVVGLSVQMV IGDPAGSSQV DGAPPSKIAV VGAGIGGSAT AHFLRQHFGP
EVQVDVFEKG EVGGRLATVS VNHHDYESGG SIIHSLNLHM QEFVKQLGLK YRRSMAGKTA
VFNGEELILE ETDWYLLDLF KLWWRYGISF IRLQMWVEEI MEKFMRIYKY QAHGYAFSSV
EELLESLGGS GFINMTRRSL SDSLLELGVS QRFIDEVIAP VMRVNYGQNV SIPAFVGAVS
LAGAQNNLWA VEGGNKLVCS GLLKIANANL LQANVISISL VPSEAPQYQL SYTTATGTGS
ELYDIVVLAT PLQESVGSGV LFQGFSPPFD QLPGNYHGTV ATIVHGYLNT SFFGFPDPRL
FPFTCILTTE EPNLFFNSVA NVCPVNISAS FRRKQPQEAG VYKVFSLRPL DKAQLKTLFR
SYYSVQVTEW QAYPCYSSHQ GLPPVELHPN LYYLNGIESV ASAMEMSSVA AKNIALLAYH
RWNRQTDMVD QRDLMHRIKT EL
//
