ID H2UDS7_TAKRU Unreviewed; 824 AA.
AC H2UDS7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN Name=LOC101076248 {ECO:0000313|Ensembl:ENSTRUP00000035096.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035096.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000035096.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000035096.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
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DR RefSeq; XP_011606645.1; XM_011608343.1.
DR AlphaFoldDB; H2UDS7; -.
DR STRING; 31033.ENSTRUP00000035096; -.
DR Ensembl; ENSTRUT00000035224.3; ENSTRUP00000035096.2; ENSTRUG00000013737.3.
DR GeneID; 101076248; -.
DR KEGG; tru:101076248; -.
DR CTD; 6549; -.
DR eggNOG; KOG1966; Eukaryota.
DR GeneTree; ENSGT00940000156807; -.
DR InParanoid; H2UDS7; -.
DR OMA; INMFRTI; -.
DR OrthoDB; 1065060at2759; -.
DR TreeFam; TF317212; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.2020; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR InterPro; IPR032103; NHE_CaM-bd.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF89; SODIUM_HYDROGEN EXCHANGER 2; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF16644; NEXCaM_BD; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..824
FT /note="Sodium/hydrogen exchanger"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017451014"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..474
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 568..680
FT /note="Sodium/hydrogen exchanger regulatory region"
FT /evidence="ECO:0000259|Pfam:PF16644"
FT REGION 687..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 824 AA; 92887 MW; AA36D968DD2E62F0 CRC64;
MELRFPSQTG FFIIVFTFLI FLHGSRGEIP AKPSPSVTIL PPVKPDNGPQ AFPDAEKANL
PVFTMDYPRI QIPFEITLWM LLASFAKIGF HVYHKITIWV PETCLLISIG LIVGGIMHSV
HEEPPAVLTS SVFFLYMLPP IVLDAGYFMP TRAFFENIGT VLWFAVVGTL WNSIGIGMSL
FAICQIEAFG VQDINLQENL LFASIISAVD PVAVLSVFED VSVNEALYIV VFGECLFNDA
VTVVLYNMFT FVAEMPVVEP VDVFLGVARF FVVGLGGMGF GILFGFAASF TTRFTSRVRE
IEPLFIFMYS YLAYLVAELF AISSIMAIVT CALTMKYYVE ENVSQRSCTT IRHVVKMLGS
ISETLIFFFL GVVTVTTEHE WNWAYILFTL FFAFVWRGLG VLVLTQIINP FRTIPFNMKD
QFGLAYGGLR GAISFALAFT LPENIGRKQL FVTATIVIIL FTVFLQGISI RPLIEFINVR
RTNRNLDTIN VEIHCRLMEH TIAGIEDLCG QWSRHYWKDK FMIFNNRFLR RILIRDSRAE
SSIVALYKKL ELQNAMEILD TVAGDISAAP SIVSLYEEKK NSPTPTISTT KPKKKFLASD
LRNMHNILSK NMYKIRQRTV AFRGKHALPN DIQTREILIR RHSTIRRSLR PGSFQTSMVP
KSQKYFSLPA GKSLDSRFPS VRSNYADQQE TMSEVAYPSN RSRFGQPARH SSRAMMPLRR
LDTLREMSSV NTLEESTANQ RDRTGAGVSR TKSSSSDSHL PAPRHHLRSA DDSGSADHPR
NGHQEVEADE EEASSPPPAW AAEARDGAAQ NPLLRRPQWN PKKM
//
