ID   H2UDZ0_TAKRU            Unreviewed;       759 AA.
AC   H2UDZ0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 21 {ECO:0000256|ARBA:ARBA00020102};
DE   AltName: Full=Coiled-coil domain-containing protein 128 {ECO:0000256|ARBA:ARBA00031617};
DE   AltName: Full=KLRAQ motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031361};
GN   Name=ppp1r21 {ECO:0000313|Ensembl:ENSTRUP00000035159.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035159.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000035159.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000035159.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC       Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR   AlphaFoldDB; H2UDZ0; -.
DR   Ensembl; ENSTRUT00000035287.3; ENSTRUP00000035159.3; ENSTRUG00000013766.3.
DR   GeneTree; ENSGT00390000006820; -.
DR   HOGENOM; CLU_022372_0_0_1; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR049372; PPP1R21_C.
DR   InterPro; IPR019343; PPP1R21_N.
DR   InterPro; IPR019348; PPP1R21_six_helix.
DR   PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR   PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF21636; PPP1R21_C; 1.
DR   Pfam; PF10212; PPP1R21_helical; 1.
DR   SMART; SM01254; KLRAQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   DOMAIN          12..113
FT                   /note="Protein phosphatase 1 regulatory subunit 21 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM01254"
FT   REGION          740..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          4..87
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          131..218
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          552..614
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          675..716
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   759 AA;  86314 MW;  B979D7186C4BC644 CRC64;
     MANVTDLQTK YSKLAQEYSK LRAQNQVLKK AVVDEQANCV SLKDQLKQRD QSLRKQEQEM
     DSLSFRNQQL AKRVELLQEE LAVCEAKGKK GKNKGDSPSQ HALETKNVFD EDLQKKIEEN
     ERLHIQFYEA DELHKRQEAQ LRARLQELER EAEQHQDAVN GLNTKYTDTI ERLHSDKARL
     ELKTQTMERE AQECRMRAED CQQQLRRCQT ELSRQVKQSS SVIQEKVPFN DTKFVHYNSL
     NVPPHNRRHQ LKARDVVGQA LSFIQDLVAA LLNFHSYTEQ RVHIYPRDSS IEPISALNQK
     FSQYLHENAA YVRPLEESFL QLHQSITEDT VTVLETVVKL KSFADHFSSY VQFLKKILPY
     QLKSLEEECE APLCTAALTA KNQELHGDMK RVTSMFEKLQ NYINVLALPS KLASTSAVFT
     QLAGCLHSLH DAIKEMSKHY NQKAGLEQEL PTVTQKLLTT SECLLGSLGS LTSSTGKIAT
     FFSNNLDFFT SPAYSPKGST VALSPLQAET MLANKKKASA YISAIKKPRP QSVPYSEALS
     NRRILTSSTE SREGLTQQVQ QSLEKIARLE QEKEHWLLEA QLGKVRLEKE NQRIADLEAQ
     LAAAESTAAG KELTWACCAQ PLQSSIIPMF GLCLQVGDEE SREQLIKTHY MARVGELTTQ
     LQISDSKAVH FHSECRALAK RLAIAEKSRE SLSEDVKRAN QNITRLQDEL TTTKRSYEDQ
     LSMMSDHLCS MNETLSKQRE EIDTLKLGSK GNAKKNKGR
//